SGC-CAMKK2-1: A Chemical Probe for CAMKK2.
| dc.contributor.author | Wells, Carrow | |
| dc.contributor.author | Liang, Yi | |
| dc.contributor.author | Pulliam, Thomas L | |
| dc.contributor.author | Lin, Chenchu | |
| dc.contributor.author | Awad, Dominik | |
| dc.contributor.author | Eduful, Benjamin | |
| dc.contributor.author | O'Byrne, Sean | |
| dc.contributor.author | Hossain, Mohammad Anwar | |
| dc.contributor.author | Catta-Preta, Carolina Moura Costa | |
| dc.contributor.author | Ramos, Priscila Zonzini | |
| dc.contributor.author | Gileadi, Opher | |
| dc.contributor.author | Gileadi, Carina | |
| dc.contributor.author | Couñago, Rafael M | |
| dc.contributor.author | Stork, Brittany | |
| dc.contributor.author | Langendorf, Christopher G | |
| dc.contributor.author | Nay, Kevin | |
| dc.contributor.author | Oakhill, Jonathan S | |
| dc.contributor.author | Mukherjee, Debarati | |
| dc.contributor.author | Racioppi, Luigi | |
| dc.contributor.author | Means, Anthony R | |
| dc.contributor.author | York, Brian | |
| dc.contributor.author | McDonnell, Donald P | |
| dc.contributor.author | Scott, John W | |
| dc.contributor.author | Frigo, Daniel E | |
| dc.contributor.author | Drewry, David H | |
| dc.date.accessioned | 2023-03-01T14:21:27Z | |
| dc.date.available | 2023-03-01T14:21:27Z | |
| dc.date.issued | 2023-01 | |
| dc.date.updated | 2023-03-01T14:21:22Z | |
| dc.description.abstract | The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, a selective chemical probe that targets CAMKK2. | |
| dc.identifier | cells12020287 | |
| dc.identifier.issn | 2073-4409 | |
| dc.identifier.issn | 2073-4409 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | MDPI AG | |
| dc.relation.ispartof | Cells | |
| dc.relation.isversionof | 10.3390/cells12020287 | |
| dc.subject | CAMKK2 | |
| dc.subject | NanoBRET | |
| dc.subject | chemical probe | |
| dc.subject | kinase | |
| dc.subject | kinase selectivity | |
| dc.title | SGC-CAMKK2-1: A Chemical Probe for CAMKK2. | |
| dc.type | Journal article | |
| duke.contributor.orcid | McDonnell, Donald P|0000-0002-7331-4700 | |
| pubs.begin-page | 287 | |
| pubs.issue | 2 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Cell Biology | |
| pubs.organisational-group | Pharmacology & Cancer Biology | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Medicine, Endocrinology, Metabolism, and Nutrition | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Medicine, Hematologic Malignancies and Cellular Therapy | |
| pubs.publication-status | Published | |
| pubs.volume | 12 |
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