Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.
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2014-08
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Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating nervous tissue, yet its mechanisms of effect are poorly understood. Here we report new methods for studying the influence of TMS on single neurons in the brain of alert non-human primates. We designed a TMS coil that focuses its effect near the tip of a recording electrode and recording electronics that enable direct acquisition of neuronal signals at the site of peak stimulus strength minimally perturbed by stimulation artifact in awake monkeys (Macaca mulatta). We recorded action potentials within ∼1 ms after 0.4-ms TMS pulses and observed changes in activity that differed significantly for active stimulation as compared with sham stimulation. This methodology is compatible with standard equipment in primate laboratories, allowing easy implementation. Application of these tools will facilitate the refinement of next generation TMS devices, experiments and treatment protocols.
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Mueller, Jerel K, Erinn M Grigsby, Vincent Prevosto, Frank W Petraglia, Hrishikesh Rao, Zhi-De Deng, Angel V Peterchev, Marc A Sommer, et al. (2014). Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates. Nat Neurosci, 17(8). pp. 1130–1136. 10.1038/nn.3751 Retrieved from https://hdl.handle.net/10161/9482.
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Marc A. Sommer
We study circuits for cognition. Using a combination of neurophysiology and biomedical engineering, we focus on the interaction between brain areas during visual perception, decision-making, and motor planning. Specific projects include the role of frontal cortex in metacognition, the role of cerebellar-frontal circuits in action timing, the neural basis of "good enough" decision-making (satisficing), and the neural mechanisms of transcranial magnetic stimulation (TMS).
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