Acute administration of unacylated ghrelin has no effect on Basal or stimulated insulin secretion in healthy humans.

Tong, Jenny

Davis, Harold W

Summer, Suzanne

Benoit, Stephen C

Haque, Ahrar

Bidlingmaier, Martin

Tschöp, Matthias H

D'Alessio, David

United States

2016-08-10T20:59:18Z

2014-07

Unacylated ghrelin (UAG) is the predominant ghrelin isoform in the circulation. Despite its inability to activate the classical ghrelin receptor, preclinical studies suggest that UAG may promote β-cell function. We hypothesized that UAG would oppose the effects of acylated ghrelin (AG) on insulin secretion and glucose tolerance. AG (1 µg/kg/h), UAG (4 µg/kg/h), combined AG+UAG, or saline were infused to 17 healthy subjects (9 men and 8 women) on four occasions in randomized order. Ghrelin was infused for 30 min to achieve steady-state levels and continued through a 3-h intravenous glucose tolerance test. The acute insulin response to glucose (AIRg), insulin sensitivity index (SI), disposition index (DI), and intravenous glucose tolerance (kg) were compared for each subject during the four infusions. AG infusion raised fasting glucose levels but had no effect on fasting plasma insulin. Compared with the saline control, AG and AG+UAG both decreased AIRg, but UAG alone had no effect. SI did not differ among the treatments. AG, but not UAG, reduced DI and kg and increased plasma growth hormone. UAG did not alter growth hormone, cortisol, glucagon, or free fatty acid levels. UAG selectively decreased glucose and fructose consumption compared with the other treatments. In contrast to previous reports, acute administration of UAG does not have independent effects on glucose tolerance or β-cell function and neither augments nor antagonizes the effects of AG.

http://www.ncbi.nlm.nih.gov/pubmed/24550190

db13-1598

1939-327X

https://hdl.handle.net/10161/12642

eng

American Diabetes Association

Diabetes

10.2337/db13-1598

Adolescent

Adult

Basal Metabolism

Blood Glucose

Drug Administration Schedule

Female

Ghrelin

Health

Humans

Insulin

Insulin-Secreting Cells

Male

Middle Aged

Young Adult

Acute administration of unacylated ghrelin has no effect on Basal or stimulated insulin secretion in healthy humans.

Journal article

D'Alessio, David|0000-0003-4155-4870

http://www.ncbi.nlm.nih.gov/pubmed/24550190

2309

2319

7

Clinical Science Departments

Duke

Duke Molecular Physiology Institute

Institutes and Centers

Medicine

Medicine, Endocrinology, Metabolism, and Nutrition

School of Medicine

Published

63