The association between cognitive function and subsequent depression: a systematic review and meta-analysis.

Scult, MA

Paulli, AR

Mazure, ES

Moffitt, TE

Hariri, AR

Strauman, TJ

England

2017-03-16T22:15:31Z

2017-03-16T22:15:31Z

2017-01

Despite a growing interest in understanding the cognitive deficits associated with major depressive disorder (MDD), it is largely unknown whether such deficits exist before disorder onset or how they might influence the severity of subsequent illness. The purpose of the present study was to conduct a systematic review and meta-analysis of longitudinal datasets to determine whether cognitive function acts as a predictor of later MDD diagnosis or change in depression symptoms. Eligible studies included longitudinal designs with baseline measures of cognitive functioning, and later unipolar MDD diagnosis or symptom assessment. The systematic review identified 29 publications, representing 34 unique samples, and 121 749 participants, that met the inclusion/exclusion criteria. Quantitative meta-analysis demonstrated that higher cognitive function was associated with decreased levels of subsequent depression (r = -0.088, 95% confidence interval. -0.121 to -0.054, p < 0.001). However, sensitivity analyses revealed that this association is likely driven by concurrent depression symptoms at the time of cognitive assessment. Our review and meta-analysis indicate that the association between lower cognitive function and later depression is confounded by the presence of contemporaneous depression symptoms at the time of cognitive assessment. Thus, cognitive deficits predicting MDD likely represent deleterious effects of subclinical depression symptoms on performance rather than premorbid risk factors for disorder.

https://www.ncbi.nlm.nih.gov/pubmed/27624847

S0033291716002075

1469-8978

https://hdl.handle.net/10161/13834

eng

Cambridge University Press (CUP)

Psychol Med

10.1017/S0033291716002075

Cognitive function

depression

intelligence

longitudinal

premorbid

risk

The association between cognitive function and subsequent depression: a systematic review and meta-analysis.

Journal article

Scult, MA|0000-0001-5554-8186

Mazure, ES|0000-0002-9426-4853

Moffitt, TE|0000-0002-8589-6760

Strauman, TJ|0000-0002-0310-4505

https://www.ncbi.nlm.nih.gov/pubmed/27624847

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Center for Child and Family Policy

Center for Population Health & Aging

Clinical Science Departments

Duke

Duke Institute for Brain Sciences

Duke Population Research Center

Duke Population Research Institute

Duke Science & Society

Duke-UNC Center for Brain Imaging and Analysis

Initiatives

Institutes and Centers

Institutes and Provost's Academic Units

Psychiatry, Child & Family Mental Health and Developmental Neuroscience

Psychiatry & Behavioral Sciences

Psychology and Neuroscience

Sanford School of Public Policy

School of Medicine

Staff

Trinity College of Arts & Sciences

University Institutes and Centers

Published

47