Clinical characteristics, racial inequities, and outcomes in patients with breast cancer and COVID-19: A COVID-19 and cancer consortium (CCC19) cohort study.
| dc.contributor.author | Nagaraj, Gayathri | |
| dc.contributor.author | Vinayak, Shaveta | |
| dc.contributor.author | Khaki, Ali Raza | |
| dc.contributor.author | Sun, Tianyi | |
| dc.contributor.author | Kuderer, Nicole M | |
| dc.contributor.author | Aboulafia, David M | |
| dc.contributor.author | Acoba, Jared D | |
| dc.contributor.author | Awosika, Joy | |
| dc.contributor.author | Bakouny, Ziad | |
| dc.contributor.author | Balmaceda, Nicole B | |
| dc.contributor.author | Bao, Ting | |
| dc.contributor.author | Bashir, Babar | |
| dc.contributor.author | Berg, Stephanie | |
| dc.contributor.author | Bilen, Mehmet A | |
| dc.contributor.author | Bindal, Poorva | |
| dc.contributor.author | Blau, Sibel | |
| dc.contributor.author | Bodin, Brianne E | |
| dc.contributor.author | Borno, Hala T | |
| dc.contributor.author | Castellano, Cecilia | |
| dc.contributor.author | Choi, Horyun | |
| dc.contributor.author | Deeken, John | |
| dc.contributor.author | Desai, Aakash | |
| dc.contributor.author | Edwin, Natasha | |
| dc.contributor.author | Feldman, Lawrence E | |
| dc.contributor.author | Flora, Daniel B | |
| dc.contributor.author | Friese, Christopher R | |
| dc.contributor.author | Galsky, Matthew D | |
| dc.contributor.author | Gonzalez, Cyndi J | |
| dc.contributor.author | Grivas, Petros | |
| dc.contributor.author | Gupta, Shilpa | |
| dc.contributor.author | Haynam, Marcy | |
| dc.contributor.author | Heilman, Hannah | |
| dc.contributor.author | Hershman, Dawn L | |
| dc.contributor.author | Hwang, Clara | |
| dc.contributor.author | Jani, Chinmay | |
| dc.contributor.author | Jhawar, Sachin R | |
| dc.contributor.author | Joshi, Monika | |
| dc.contributor.author | Kaklamani, Virginia | |
| dc.contributor.author | Klein, Elizabeth J | |
| dc.contributor.author | Knox, Natalie | |
| dc.contributor.author | Koshkin, Vadim S | |
| dc.contributor.author | Kulkarni, Amit A | |
| dc.contributor.author | Kwon, Daniel H | |
| dc.contributor.author | Labaki, Chris | |
| dc.contributor.author | Lammers, Philip E | |
| dc.contributor.author | Lathrop, Kate I | |
| dc.contributor.author | Lewis, Mark A | |
| dc.contributor.author | Li, Xuanyi | |
| dc.contributor.author | Lopes, Gilbert de Lima | |
| dc.contributor.author | Lyman, Gary H | |
| dc.contributor.author | Makower, Della F | |
| dc.contributor.author | Mansoor, Abdul-Hai | |
| dc.contributor.author | Markham, Merry-Jennifer | |
| dc.contributor.author | Mashru, Sandeep H | |
| dc.contributor.author | McKay, Rana R | |
| dc.contributor.author | Messing, Ian | |
| dc.contributor.author | Mico, Vasil | |
| dc.contributor.author | Nadkarni, Rajani | |
| dc.contributor.author | Namburi, Swathi | |
| dc.contributor.author | Nguyen, Ryan H | |
| dc.contributor.author | Nonato, Taylor Kristian | |
| dc.contributor.author | O'Connor, Tracey Lynn | |
| dc.contributor.author | Panagiotou, Orestis A | |
| dc.contributor.author | Park, Kyu | |
| dc.contributor.author | Patel, Jaymin M | |
| dc.contributor.author | Patel, Kanishka GopikaBimal | |
| dc.contributor.author | Peppercorn, Jeffrey | |
| dc.contributor.author | Polimera, Hyma | |
| dc.contributor.author | Puc, Matthew | |
| dc.contributor.author | Rao, Yuan James | |
| dc.contributor.author | Razavi, Pedram | |
| dc.contributor.author | Reid, Sonya A | |
| dc.contributor.author | Riess, Jonathan W | |
| dc.contributor.author | Rivera, Donna R | |
| dc.contributor.author | Robson, Mark | |
| dc.contributor.author | Rose, Suzanne J | |
| dc.contributor.author | Russ, Atlantis D | |
| dc.contributor.author | Schapira, Lidia | |
| dc.contributor.author | Shah, Pankil K | |
| dc.contributor.author | Shanahan, M Kelly | |
| dc.contributor.author | Shapiro, Lauren C | |
| dc.contributor.author | Smits, Melissa | |
| dc.contributor.author | Stover, Daniel G | |
| dc.contributor.author | Streckfuss, Mitrianna | |
| dc.contributor.author | Tachiki, Lisa | |
| dc.contributor.author | Thompson, Michael A | |
| dc.contributor.author | Tolaney, Sara M | |
| dc.contributor.author | Weissmann, Lisa B | |
| dc.contributor.author | Wilson, Grace | |
| dc.contributor.author | Wotman, Michael T | |
| dc.contributor.author | Wulff-Burchfield, Elizabeth M | |
| dc.contributor.author | Mishra, Sanjay | |
| dc.contributor.author | French, Benjamin | |
| dc.contributor.author | Warner, Jeremy L | |
| dc.contributor.author | Lustberg, Maryam B | |
| dc.contributor.author | Accordino, Melissa K | |
| dc.contributor.author | Shah, Dimpy P | |
| dc.contributor.author | COVID-19 and Cancer Consortium | |
| dc.date.accessioned | 2024-10-01T17:35:46Z | |
| dc.date.available | 2024-10-01T17:35:46Z | |
| dc.date.issued | 2023-10 | |
| dc.description.abstract | BackgroundLimited information is available for patients with breast cancer (BC) and coronavirus disease 2019 (COVID-19), especially among underrepresented racial/ethnic populations.MethodsThis is a COVID-19 and Cancer Consortium (CCC19) registry-based retrospective cohort study of females with active or history of BC and laboratory-confirmed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection diagnosed between March 2020 and June 2021 in the US. Primary outcome was COVID-19 severity measured on a five-level ordinal scale, including none of the following complications, hospitalization, intensive care unit admission, mechanical ventilation, and all-cause mortality. Multivariable ordinal logistic regression model identified characteristics associated with COVID-19 severity.Results1383 female patient records with BC and COVID-19 were included in the analysis, the median age was 61 years, and median follow-up was 90 days. Multivariable analysis revealed higher odds of COVID-19 severity for older age (aOR per decade, 1.48 [95% CI, 1.32-1.67]); Black patients (aOR 1.74; 95 CI 1.24-2.45), Asian Americans and Pacific Islander patients (aOR 3.40; 95 CI 1.70-6.79) and Other (aOR 2.97; 95 CI 1.71-5.17) racial/ethnic groups; worse ECOG performance status (ECOG PS ≥2: aOR, 7.78 [95% CI, 4.83-12.5]); pre-existing cardiovascular (aOR, 2.26 [95% CI, 1.63-3.15])/pulmonary comorbidities (aOR, 1.65 [95% CI, 1.20-2.29]); diabetes mellitus (aOR, 2.25 [95% CI, 1.66-3.04]); and active and progressing cancer (aOR, 12.5 [95% CI, 6.89-22.6]). Hispanic ethnicity, timing, and type of anti-cancer therapy modalities were not significantly associated with worse COVID-19 outcomes. The total all-cause mortality and hospitalization rate for the entire cohort was 9% and 37%, respectively however, it varied according to the BC disease status.ConclusionsUsing one of the largest registries on cancer and COVID-19, we identified patient and BC-related factors associated with worse COVID-19 outcomes. After adjusting for baseline characteristics, underrepresented racial/ethnic patients experienced worse outcomes compared to non-Hispanic White patients.FundingThis study was partly supported by National Cancer Institute grant number P30 CA068485 to Tianyi Sun, Sanjay Mishra, Benjamin French, Jeremy L Warner; P30-CA046592 to Christopher R Friese; P30 CA023100 for Rana R McKay; P30-CA054174 for Pankil K Shah and Dimpy P Shah; KL2 TR002646 for Pankil Shah and the American Cancer Society and Hope Foundation for Cancer Research (MRSG-16-152-01-CCE) and P30-CA054174 for Dimpy P Shah. REDCap is developed and supported by Vanderbilt Institute for Clinical and Translational Research grant support (UL1 TR000445 from NCATS/NIH). The funding sources had no role in the writing of the manuscript or the decision to submit it for publication.Clinical trial numberCCC19 registry is registered on ClinicalTrials.gov, NCT04354701. | |
| dc.identifier | 82618 | |
| dc.identifier.issn | 2050-084X | |
| dc.identifier.issn | 2050-084X | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.relation.ispartof | eLife | |
| dc.relation.isversionof | 10.7554/elife.82618 | |
| dc.rights.uri | ||
| dc.subject | COVID-19 and Cancer Consortium | |
| dc.subject | Humans | |
| dc.subject | Breast Neoplasms | |
| dc.subject | Retrospective Studies | |
| dc.subject | Cohort Studies | |
| dc.subject | Middle Aged | |
| dc.subject | United States | |
| dc.subject | Female | |
| dc.subject | COVID-19 | |
| dc.subject | SARS-CoV-2 | |
| dc.title | Clinical characteristics, racial inequities, and outcomes in patients with breast cancer and COVID-19: A COVID-19 and cancer consortium (CCC19) cohort study. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Lyman, Gary H|0000-0002-0823-8086 | |
| pubs.begin-page | e82618 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Medicine, Medical Oncology | |
| pubs.publication-status | Published | |
| pubs.volume | 12 |
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