The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer.

dc.contributor.author

Hammouda, Manel B

dc.contributor.author

Ford, Amy E

dc.contributor.author

Liu, Yuan

dc.contributor.author

Zhang, Jennifer Y

dc.date.accessioned

2021-10-01T15:45:08Z

dc.date.available

2021-10-01T15:45:08Z

dc.date.issued

2020-04-02

dc.date.updated

2021-10-01T15:45:05Z

dc.description.abstract

The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, apoptosis, and inflammation. Dysregulation of JNK pathway is associated with a wide range of immune disorders and cancer. Our objective is to provide a review of JNK proteins and their upstream regulators and downstream effector molecules in common skin disorders, including psoriasis, dermal fibrosis, scleroderma, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma.

dc.identifier

cells9040857

dc.identifier.issn

2073-4409

dc.identifier.issn

2073-4409

dc.identifier.uri

https://hdl.handle.net/10161/23887

dc.language

eng

dc.publisher

MDPI AG

dc.relation.ispartof

Cells

dc.relation.isversionof

10.3390/cells9040857

dc.subject

Humans

dc.subject

Neoplasms

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Skin Diseases

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JNK Mitogen-Activated Protein Kinases

dc.subject

Signal Transduction

dc.title

The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer.

dc.type

Journal article

duke.contributor.orcid

Zhang, Jennifer Y|0000-0002-4485-1750

pubs.begin-page

857

pubs.end-page

857

pubs.issue

4

pubs.organisational-group

School of Medicine

pubs.organisational-group

Duke Cancer Institute

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Dermatology

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Pathology

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Duke

pubs.organisational-group

Institutes and Centers

pubs.organisational-group

Clinical Science Departments

pubs.publication-status

Published

pubs.volume

9

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