A prospective study of Escherichia coli bloodstream infection among adolescents and adults in northern Tanzania.
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2020-05
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Abstract
Background
Characterization of the epidemiology of Escherichia coli bloodstream infection (BSI) in sub-Saharan Africa is lacking. We studied patients with E. coli BSI in northern Tanzania to describe host risk factors for infection and to describe the antimicrobial susceptibility of isolates.Methods
Within 24 h of admission, patients presenting with a fever at two hospitals in Moshi, Tanzania, were screened and enrolled. Cases were patients with at least one blood culture yielding E. coli and controls were those without E. coli isolated from any blood culture. Logistic regression was used to identify host risk factors for E. coli BSI.Results
We analyzed data from 33 cases and 1615 controls enrolled from 2007 through 2018. The median (IQR) age of cases was 47 (34-57) y and 24 (72.7%) were female. E. coli BSI was associated with (adjusted OR [aOR], 95% CI) increasing years of age (1.03, 1.01 to 1.05), female gender (2.20, 1.01 to 4.80), abdominal tenderness (2.24, 1.06 to 4.72) and urinary tract infection as a discharge diagnosis (3.71, 1.61 to 8.52). Of 31 isolates with antimicrobial susceptibility results, the prevalence of resistance was ampicillin 29 (93.6%), ceftriaxone three (9.7%), ciprofloxacin five (16.1%), gentamicin seven (22.6%) and trimethoprim-sulfamethoxazole 31 (100.0%).Conclusions
In Tanzania, host risk factors for E. coli BSI were similar to those reported in high-resource settings and resistance to key antimicrobials was common.Type
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Madut, Deng B, Matthew P Rubach, Nathaniel Kalengo, Manuela Carugati, Michael J Maze, Anne B Morrissey, Blandina T Mmbaga, Bingileki F Lwezaula, et al. (2020). A prospective study of Escherichia coli bloodstream infection among adolescents and adults in northern Tanzania. Transactions of the Royal Society of Tropical Medicine and Hygiene, 114(5). pp. 378–384. 10.1093/trstmh/trz111 Retrieved from https://hdl.handle.net/10161/29841.
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Scholars@Duke
![Madut](https://scholars.duke.edu/profile-images/thumbnail200/0593544.jpg)
Deng Madut
I am an infectious diseases doctor who specializes in the care of patients with general infectious diseases, including persons living with HIV. My research is focused on improving the diagnosis and treatment of infectious diseases among populations living in low-resource settings.
![Rubach](https://scholars.duke.edu/profile-images/thumbnail200/0562726.jpg)
Matthew P. Rubach
![Carugati](https://scholars.duke.edu/profile-images/thumbnail200/0599860.jpg)
Manuela Carugati
Blandina Mmbaga
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