Successes and Challenges on the Road to Cure Hepatitis C.

Studying the RNA biology, cell biology, and immunology of RNA virus infection

Our lab studies the molecular mechanisms that regulate RNA virus-host interactions. We focus primarily on viruses in the Flaviviridae family of viruses, including dengue virus (DENV), Zika virus (ZIKV), and hepatitis C virus (HCV). Our research is focused on defining (1) how these viruses replicate, (2) the mechanisms that regulate antiviral innate immunity to these viruses, and (3) RNA regulatory controls to both of these processes. Our lab has pioneered approaches to how the RNA modification m6A regulates viral infection, antiviral innate immunity and the host response to virus infection. Our long-term goal is to discover the necessary mechanistic and functional information to guide future development of new strategies for virus treatment and prevention.

Lab Website

Dr. Susanna Naggie completed her undergraduate degrees in chemical engineering and biochemistry at the University of Maryland, College Park, and her medical education at Johns Hopkins School of Medicine. She conducted her internal medicine and infectious diseases fellowship training at Duke University Medical Center, where she also served as Chief Resident. She joined the faculty in the Duke School of Medicine in 2009. She is a Professor of Medicine and currently holds appointments at the Duke University School of Medicine, at the Duke Clinical Research Institute, and at the Durham Veterans Affairs Medical Center. Dr. Naggie is a clinical investigator with a focus in clinical trials in infectious diseases and translational research in HIV and liver disease. She is a standing member of the DHHS Panel on Antiretroviral Guidelines for Adults and Adolescents and the CDC/NIH/IDSA-HIVMA Opportunistic Infections Guideline. She is the Vice Dean for Clinical and Translational Research and Director for the Duke Clinical and Translational Sciences Institute.