Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children.
dc.contributor.author | Kulminski, Alexander M | |
dc.contributor.author | Arbeev, Konstantin G | |
dc.contributor.author | Christensen, Kaare | |
dc.contributor.author | Stallard, Eric | |
dc.contributor.author | Miljkovic, Iva | |
dc.contributor.author | Barmada, Michael | |
dc.contributor.author | Yashin, Anatoliy I | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2017-06-06T19:21:54Z | |
dc.date.available | 2017-06-06T19:21:54Z | |
dc.date.issued | 2013-07 | |
dc.description.abstract | This study focuses on the participants of the Long Life Family Study to elucidate whether biogenetic mechanisms underlying relationships among heritable complex phenotypes in parents function in the same way for the same phenotypes in their children. Our results reveal 3 characteristic groups of relationships among phenotypes in parents and children. One group composed of 3 pairs of phenotypes confirms that associations among some phenotypes can be explained by the same biogenetic mechanisms working in parents and children. Two other groups including 9 phenotype pairs show that this is not a common rule. Our findings suggest that biogenetic mechanisms underlying relationships among different phenotypes, even if they are causally related, can function differently in successive generations or in different age groups of biologically related individuals. The results suggest that the role of aging-related processes in changing environment may be conceptually underestimated in current genetic association studies using genome wide resources. | |
dc.identifier | ||
dc.identifier | gls243 | |
dc.identifier.eissn | 1758-535X | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Oxford University Press (OUP) | |
dc.relation.ispartof | J Gerontol A Biol Sci Med Sci | |
dc.relation.isversionof | 10.1093/gerona/gls243 | |
dc.subject | Aging | |
dc.subject | Disease | |
dc.subject | Genetics of healthspan | |
dc.subject | Heritability | |
dc.subject | Longevity regulation | |
dc.subject | Adult Children | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Aging | |
dc.subject | Environment | |
dc.subject | Epigenesis, Genetic | |
dc.subject | Female | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Genotype | |
dc.subject | Humans | |
dc.subject | Longevity | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Parents | |
dc.subject | Phenotype | |
dc.title | Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children. | |
dc.type | Journal article | |
duke.contributor.orcid | Arbeev, Konstantin G|0000-0002-4195-7832 | |
pubs.author-url | ||
pubs.begin-page | 760 | |
pubs.end-page | 768 | |
pubs.issue | 7 | |
pubs.organisational-group | Center for Population Health & Aging | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Duke Cancer Institute | |
pubs.organisational-group | Duke Population Research Center | |
pubs.organisational-group | Duke Population Research Institute | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Institutes and Provost's Academic Units | |
pubs.organisational-group | Sanford School of Public Policy | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Social Science Research Institute | |
pubs.organisational-group | Staff | |
pubs.organisational-group | University Institutes and Centers | |
pubs.publication-status | Published | |
pubs.volume | 68 |
Files
Original bundle
- Name:
- Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children.pdf
- Size:
- 607.93 KB
- Format:
- Adobe Portable Document Format