Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children.

dc.contributor.author

Kulminski, Alexander M

dc.contributor.author

Arbeev, Konstantin G

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Christensen, Kaare

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Stallard, Eric

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Miljkovic, Iva

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Barmada, Michael

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Yashin, Anatoliy I

dc.coverage.spatial

United States

dc.date.accessioned

2017-06-06T19:21:54Z

dc.date.available

2017-06-06T19:21:54Z

dc.date.issued

2013-07

dc.description.abstract

This study focuses on the participants of the Long Life Family Study to elucidate whether biogenetic mechanisms underlying relationships among heritable complex phenotypes in parents function in the same way for the same phenotypes in their children. Our results reveal 3 characteristic groups of relationships among phenotypes in parents and children. One group composed of 3 pairs of phenotypes confirms that associations among some phenotypes can be explained by the same biogenetic mechanisms working in parents and children. Two other groups including 9 phenotype pairs show that this is not a common rule. Our findings suggest that biogenetic mechanisms underlying relationships among different phenotypes, even if they are causally related, can function differently in successive generations or in different age groups of biologically related individuals. The results suggest that the role of aging-related processes in changing environment may be conceptually underestimated in current genetic association studies using genome wide resources.

dc.identifier

https://www.ncbi.nlm.nih.gov/pubmed/23213029

dc.identifier

gls243

dc.identifier.eissn

1758-535X

dc.identifier.uri

https://hdl.handle.net/10161/14870

dc.language

eng

dc.publisher

Oxford University Press (OUP)

dc.relation.ispartof

J Gerontol A Biol Sci Med Sci

dc.relation.isversionof

10.1093/gerona/gls243

dc.subject

Aging

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Disease

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Genetics of healthspan

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Heritability

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Longevity regulation

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Adult Children

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Aged

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Aged, 80 and over

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Aging

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Environment

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Epigenesis, Genetic

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Female

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Genetic Predisposition to Disease

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Genotype

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Humans

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Longevity

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Male

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Middle Aged

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Parents

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Phenotype

dc.title

Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children.

dc.type

Journal article

duke.contributor.orcid

Arbeev, Konstantin G|0000-0002-4195-7832

pubs.author-url

https://www.ncbi.nlm.nih.gov/pubmed/23213029

pubs.begin-page

760

pubs.end-page

768

pubs.issue

7

pubs.organisational-group

Center for Population Health & Aging

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Duke

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Duke Cancer Institute

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Duke Population Research Center

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Duke Population Research Institute

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Institutes and Centers

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Institutes and Provost's Academic Units

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Sanford School of Public Policy

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School of Medicine

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Social Science Research Institute

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Staff

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University Institutes and Centers

pubs.publication-status

Published

pubs.volume

68

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