Depressive Symptoms and Incident Heart Failure in the Jackson Heart Study: Differential Risk Among Black Men and Women.

Gaffey, Allison E

Cavanagh, Casey E

Rosman, Lindsey

Wang, Kaicheng

Deng, Yanhong

Sims, Mario

O'Brien, Emily C

Chamberlain, Alanna M

Mentz, Robert J

Glover, LáShauntá M

Glover, LáShauntá M

Burg, Matthew M

2023-01-30T17:49:59Z

2023-01-30T17:49:59Z

2022-03

2023-01-30T17:49:57Z

Background Associations between depression, incident heart failure (HF), and mortality are well documented in predominately White samples. Yet, there are sparse data from racial minorities, including those who are women, and depression is underrecognized and undertreated in the Black population. Thus, we examined associations between baseline depressive symptoms, incident HF, and all-cause mortality across 10 years. Methods and Results We included Jackson Heart Study (JHS) participants with no history of HF at baseline (n=2651; 63.9% women; median age, 53 years). Cox proportional hazards models tested if the risk of incident HF or mortality differed by clinically significant depressive symptoms at baseline (Center for Epidemiological Studies-Depression scores ≥16 versus <16). Models were conducted in the full sample and by sex, with hierarchical adjustment for demographics, HF risk factors, and lifestyle factors. Overall, 538 adults (20.3%) reported high depressive symptoms (71.0% were women), and there were 181 cases of HF (cumulative incidence, 0.06%). In the unadjusted model, individuals with high depressive symptoms had a 43% greater risk of HF (P=0.035). The association remained with demographic and HF risk factors but was attenuated by lifestyle factors. All-cause mortality was similar regardless of depressive symptoms. By sex, the unadjusted association between depressive symptoms and HF remained for women only (P=0.039). The fully adjusted model showed a 53% greater risk of HF for women with high depressive symptoms (P=0.043). Conclusions Among Black adults, there were sex-specific associations between depressive symptoms and incident HF, with greater risk among women. Sex-specific management of depression may be needed to improve cardiovascular outcomes.

2047-9980

2047-9980

https://hdl.handle.net/10161/26509

eng

Ovid Technologies (Wolters Kluwer Health)

Journal of the American Heart Association

10.1161/jaha.121.022514

Humans

Incidence

Proportional Hazards Models

Risk Factors

Longitudinal Studies

Depression

Adult

Middle Aged

Female

Male

Heart Failure

Black People

Depressive Symptoms and Incident Heart Failure in the Jackson Heart Study: Differential Risk Among Black Men and Women.

Journal article

O'Brien, Emily C|0000-0002-8257-7561

Mentz, Robert J|0000-0002-3222-1719

Glover, LáShauntá M|0000-0002-1347-0189|0000-0002-7721-8169

e022514

5

Duke

School of Medicine

Basic Science Departments

Clinical Science Departments

Institutes and Centers

Medicine

Medicine, Cardiology

Duke Clinical Research Institute

Institutes and Provost's Academic Units

Neurology

Initiatives

Population Health Sciences

Duke - Margolis Center For Health Policy

Published

11