Animal models of soft-tissue sarcoma.

dc.contributor.author

Dodd, Rebecca D

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Mito, Jeffery K

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Kirsch, David G

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England

dc.date.accessioned

2011-06-21T17:27:33Z

dc.date.issued

2010-09

dc.description.abstract

Soft-tissue sarcomas (STSs) are rare mesenchymal tumors that arise from muscle, fat and connective tissue. Currently, over 75 subtypes of STS are recognized. The rarity and heterogeneity of patient samples complicate clinical investigations into sarcoma biology. Model organisms might provide traction to our understanding and treatment of the disease. Over the past 10 years, many successful animal models of STS have been developed, primarily genetically engineered mice and zebrafish. These models are useful for studying the relevant oncogenes, signaling pathways and other cell changes involved in generating STSs. Recently, these model systems have become preclinical platforms in which to evaluate new drugs and treatment regimens. Thus, animal models are useful surrogates for understanding STS disease susceptibility and pathogenesis as well as for testing potential therapeutic strategies.

dc.description.version

Version of Record

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http://www.ncbi.nlm.nih.gov/pubmed/20713645

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dmm.005223

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1754-8411

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https://hdl.handle.net/10161/4183

dc.language

eng

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en_US

dc.publisher

The Company of Biologists

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Dis Model Mech

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10.1242/dmm.005223

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Disease Models & Mechanisms

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Animals

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Disease Models, Animal

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Humans

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Karyotyping

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Sarcoma

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Transcription Factors

dc.title

Animal models of soft-tissue sarcoma.

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dc.type

Journal article

duke.date.pubdate

2010-10-sep

duke.description.issue

10-Sep

duke.description.volume

3

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/20713645

pubs.begin-page

557

pubs.end-page

566

pubs.issue

9-10

pubs.organisational-group

Basic Science Departments

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Clinical Science Departments

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Duke

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Duke Cancer Institute

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Institutes and Centers

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Pharmacology & Cancer Biology

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Radiation Oncology

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School of Medicine

pubs.publication-status

Published

pubs.volume

3

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