Network-level dynamics underlying a combined rTMS and psychotherapy treatment for major depressive disorder: An exploratory network analysis.
dc.contributor.author | Davis, Simon W | |
dc.contributor.author | Beynel, Lysianne | |
dc.contributor.author | Neacsiu, Andrada D | |
dc.contributor.author | Luber, Bruce M | |
dc.contributor.author | Bernhardt, Elisabeth | |
dc.contributor.author | Lisanby, Sarah H | |
dc.contributor.author | Strauman, Timothy J | |
dc.date.accessioned | 2023-10-03T00:28:16Z | |
dc.date.available | 2023-10-03T00:28:16Z | |
dc.date.issued | 2023-10 | |
dc.date.updated | 2023-10-03T00:28:13Z | |
dc.description.abstract | BackgroundDespite the growing use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for depression, there is a limited understanding of the mechanisms of action and how potential treatment-related brain changes help to characterize treatment response. To address this gap in understanding we investigated the effects of an approach combining rTMS with simultaneous psychotherapy on global functional connectivity.MethodWe compared task-related functional connectomes based on an idiographic goal priming task tied to emotional regulation acquired before and after simultaneous rTMS/psychotherapy treatment for patients with major depressive disorders and compared these changes to normative connectivity patterns from a set of healthy volunteers (HV) performing the same task.ResultsAt baseline, compared to HVs, patients demonstrated hyperconnectivity of the DMN, cerebellum and limbic system, and hypoconnectivity of the fronto-parietal dorsal-attention network and visual cortex. Simultaneous rTMS/psychotherapy helped to normalize these differences, which were reduced after treatment. This finding suggests that the rTMS/therapy treatment regularizes connectivity patterns in both hyperactive and hypoactive brain networks.ConclusionsThese results help to link treatment to a comprehensive model of the neurocircuitry underlying depression and pave the way for future studies using network-guided principles to significantly improve rTMS efficacy for depression. | |
dc.identifier | S1697-2600(23)00018-2 | |
dc.identifier.issn | 1697-2600 | |
dc.identifier.issn | 2174-0852 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Elsevier BV | |
dc.relation.ispartof | International journal of clinical and health psychology : IJCHP | |
dc.relation.isversionof | 10.1016/j.ijchp.2023.100382 | |
dc.subject | Depression | |
dc.subject | Functional connectivity | |
dc.subject | Self-system therapy | |
dc.subject | rTMS | |
dc.title | Network-level dynamics underlying a combined rTMS and psychotherapy treatment for major depressive disorder: An exploratory network analysis. | |
dc.type | Journal article | |
duke.contributor.orcid | Davis, Simon W|0000-0002-5943-0756 | |
duke.contributor.orcid | Neacsiu, Andrada D|0000-0002-9779-7276 | |
duke.contributor.orcid | Lisanby, Sarah H|0000-0003-2037-6470 | |
duke.contributor.orcid | Strauman, Timothy J|0000-0002-0310-4505 | |
pubs.begin-page | 100382 | |
pubs.issue | 4 | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Sanford School of Public Policy | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Trinity College of Arts & Sciences | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Pathology | |
pubs.organisational-group | Psychiatry & Behavioral Sciences | |
pubs.organisational-group | Psychology & Neuroscience | |
pubs.organisational-group | Institutes and Provost's Academic Units | |
pubs.organisational-group | University Institutes and Centers | |
pubs.organisational-group | Duke Institute for Brain Sciences | |
pubs.organisational-group | Duke-UNC Center for Brain Imaging and Analysis | |
pubs.organisational-group | Neurology | |
pubs.organisational-group | Neurology, Behavioral Neurology | |
pubs.organisational-group | Initiatives | |
pubs.organisational-group | Duke Science & Society | |
pubs.organisational-group | Center for Cognitive Neuroscience | |
pubs.organisational-group | Center for Child and Family Policy | |
pubs.organisational-group | Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences | |
pubs.organisational-group | Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology | |
pubs.publication-status | Published online | |
pubs.volume | 23 |
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