Network-level dynamics underlying a combined rTMS and psychotherapy treatment for major depressive disorder: An exploratory network analysis.

dc.contributor.author

Davis, Simon W

dc.contributor.author

Beynel, Lysianne

dc.contributor.author

Neacsiu, Andrada D

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Luber, Bruce M

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Bernhardt, Elisabeth

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Lisanby, Sarah H

dc.contributor.author

Strauman, Timothy J

dc.date.accessioned

2023-10-03T00:28:16Z

dc.date.available

2023-10-03T00:28:16Z

dc.date.issued

2023-10

dc.date.updated

2023-10-03T00:28:13Z

dc.description.abstract

Background

Despite the growing use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for depression, there is a limited understanding of the mechanisms of action and how potential treatment-related brain changes help to characterize treatment response. To address this gap in understanding we investigated the effects of an approach combining rTMS with simultaneous psychotherapy on global functional connectivity.

Method

We compared task-related functional connectomes based on an idiographic goal priming task tied to emotional regulation acquired before and after simultaneous rTMS/psychotherapy treatment for patients with major depressive disorders and compared these changes to normative connectivity patterns from a set of healthy volunteers (HV) performing the same task.

Results

At baseline, compared to HVs, patients demonstrated hyperconnectivity of the DMN, cerebellum and limbic system, and hypoconnectivity of the fronto-parietal dorsal-attention network and visual cortex. Simultaneous rTMS/psychotherapy helped to normalize these differences, which were reduced after treatment. This finding suggests that the rTMS/therapy treatment regularizes connectivity patterns in both hyperactive and hypoactive brain networks.

Conclusions

These results help to link treatment to a comprehensive model of the neurocircuitry underlying depression and pave the way for future studies using network-guided principles to significantly improve rTMS efficacy for depression.
dc.identifier

S1697-2600(23)00018-2

dc.identifier.issn

1697-2600

dc.identifier.issn

2174-0852

dc.identifier.uri

https://hdl.handle.net/10161/29084

dc.language

eng

dc.publisher

Elsevier BV

dc.relation.ispartof

International journal of clinical and health psychology : IJCHP

dc.relation.isversionof

10.1016/j.ijchp.2023.100382

dc.subject

Depression

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Functional connectivity

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Self-system therapy

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rTMS

dc.title

Network-level dynamics underlying a combined rTMS and psychotherapy treatment for major depressive disorder: An exploratory network analysis.

dc.type

Journal article

duke.contributor.orcid

Davis, Simon W|0000-0002-5943-0756

duke.contributor.orcid

Neacsiu, Andrada D|0000-0002-9779-7276

duke.contributor.orcid

Lisanby, Sarah H|0000-0003-2037-6470

duke.contributor.orcid

Strauman, Timothy J|0000-0002-0310-4505

pubs.begin-page

100382

pubs.issue

4

pubs.organisational-group

Duke

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Sanford School of Public Policy

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School of Medicine

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Trinity College of Arts & Sciences

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Clinical Science Departments

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Institutes and Centers

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Pathology

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Psychiatry & Behavioral Sciences

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Psychology & Neuroscience

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Institutes and Provost's Academic Units

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University Institutes and Centers

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Duke Institute for Brain Sciences

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Duke-UNC Center for Brain Imaging and Analysis

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Neurology

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Neurology, Behavioral Neurology

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Initiatives

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Duke Science & Society

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Center for Cognitive Neuroscience

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Center for Child and Family Policy

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Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences

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Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology

pubs.publication-status

Published online

pubs.volume

23

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