Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals.
| dc.contributor.author | Naggie, Susanna | |
| dc.contributor.author | Patel, Keyur | |
| dc.contributor.author | Yang, Lan-Yan | |
| dc.contributor.author | Chow, Shein-Chung | |
| dc.contributor.author | Johnson, Victoria | |
| dc.contributor.author | Guyton, John R | |
| dc.contributor.author | Muir, Andrew J | |
| dc.contributor.author | Sulkowski, Mark | |
| dc.contributor.author | Hicks, Charles | |
| dc.date.accessioned | 2023-03-02T15:14:48Z | |
| dc.date.available | 2023-03-02T15:14:48Z | |
| dc.date.issued | 2015-04 | |
| dc.date.updated | 2023-03-02T15:14:48Z | |
| dc.description.abstract | We evaluated the impact of antiretroviral-induced dyslipidemia on hepatitis C virus (HCV) biogenesis in human immunodeficiency virus (HIV)/HCV coinfected patients. This study used serum samples from antiretroviral-naive HIV/HCV patients initiating their first regimen as part of AIDS Clinical Trials Group study protocols (A5142, A5202). Initiation of antiretrovirals increased most lipoproteins and apolipoproteins. In the multivariable model, changes in apolipoproteins were associated with changes in log10 HCV RNA from baseline to week-24 of therapy. Off-target lipogenic changes need to be considered in the context of liver and other metabolic disease in HIV/HCV patients. | |
| dc.identifier | ofv066 | |
| dc.identifier.issn | 2328-8957 | |
| dc.identifier.issn | 2328-8957 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Oxford University Press (OUP) | |
| dc.relation.ispartof | Open forum infectious diseases | |
| dc.relation.isversionof | 10.1093/ofid/ofv066 | |
| dc.subject | HCV | |
| dc.subject | HCV RNA | |
| dc.subject | HIV | |
| dc.subject | apolipoprotein CIII | |
| dc.subject | apolipoproteins | |
| dc.subject | lipoproteins | |
| dc.title | Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Naggie, Susanna|0000-0001-7721-6975 | |
| duke.contributor.orcid | Patel, Keyur|0000-0002-4677-3127 | |
| duke.contributor.orcid | Muir, Andrew J|0000-0002-0206-1179 | |
| pubs.begin-page | ofv066 | |
| pubs.issue | 2 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Biostatistics & Bioinformatics | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Pathology | |
| pubs.organisational-group | Medicine, Endocrinology, Metabolism, and Nutrition | |
| pubs.organisational-group | Medicine, Gastroenterology | |
| pubs.organisational-group | Medicine, Infectious Diseases | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | Initiatives | |
| pubs.organisational-group | Duke Innovation & Entrepreneurship | |
| pubs.publication-status | Published | |
| pubs.volume | 2 |
Files
Original bundle
- Name:
- Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immun.pdf
- Size:
- 97.07 KB
- Format:
- Adobe Portable Document Format