Association of Biomarkers with Individual and Multiple Body Sites of Pain: The Johnston County Osteoarthritis Project.
| dc.contributor.author | Norman, Katherine S | |
| dc.contributor.author | Goode, Adam P | |
| dc.contributor.author | Alvarez, Carolina | |
| dc.contributor.author | Hu, David | |
| dc.contributor.author | George, Steven Z | |
| dc.contributor.author | Schwartz, Todd A | |
| dc.contributor.author | Danyluk, Stephanie T | |
| dc.contributor.author | Fillipo, Rebecca | |
| dc.contributor.author | Kraus, Virginia B | |
| dc.contributor.author | Huebner, Janet L | |
| dc.contributor.author | Cleveland, Rebecca J | |
| dc.contributor.author | Jordan, Joanne M | |
| dc.contributor.author | Nelson, Amanda E | |
| dc.contributor.author | Golightly, Yvonne M | |
| dc.date.accessioned | 2022-09-02T13:23:35Z | |
| dc.date.available | 2022-09-02T13:23:35Z | |
| dc.date.issued | 2022-01 | |
| dc.date.updated | 2022-09-02T13:23:35Z | |
| dc.description.abstract | IntroductionBiochemical biomarkers may provide insight into musculoskeletal pain reported at individual or multiple body sites. The purpose of this study was to determine if biomarkers or pressure-pain threshold (PPT) were associated with individual or multiple sites of pain.MethodsThis cross-sectional analysis included 689 community-based participants. Self-reported symptoms (ie, pain, aching, or stiffness) were ascertained about the neck, upper back/thoracic, low back, shoulders, elbows, wrist, hands, hips, knees, ankles, and feet. Measured analytes included CXCL-6, RANTES, HA, IL-6, BDNF, OPG and NPY. A standard dolorimeter measured PPT. Logistic regression was used determine the association between biomarkers and PPT with individual and summed sites of pain.ResultsIncreased IL-6 and HA were associated with knee pain (OR=1.30, 95% CI 1.03, 1.64) and (OR=1.32, 95% CI 1.01, 1.73) respectively; HA was also associated with elbow/wrist/hand pain (OR=1.60, 95% CI 1.22, 2.09). Those with increased NPY levels were less likely to have shoulder pain (OR=0.56, 95% CI 0.33, 0.93). Biomarkers HA (OR=1.50, 95% CI 1.07, 2.10), OPG (OR=1.74, 95% CI 1.00, 3.03), CXCL-6 (OR=1.75, 95% CI 1.02, 3.01) and decreased PPT (OR=3.97, 95% CI 2.22, 7.12) were associated with multiple compared to no sites of pain. Biomarker HA (OR=1.57, 95% CI 1.06, 2.32) and decreased PPT (OR=3.53, 95% CI 1.81, 6.88) were associated with multiple compared to a single site of pain.ConclusionBiomarkers of inflammation (HA, OPG, IL-6 and CXCL-6), pain (NPY) and PPT may help to understand the etiology of single and multiple pain sites. | |
| dc.identifier | 365187 | |
| dc.identifier.issn | 1178-7090 | |
| dc.identifier.issn | 1178-7090 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Informa UK Limited | |
| dc.relation.ispartof | Journal of pain research | |
| dc.relation.isversionof | 10.2147/jpr.s365187 | |
| dc.subject | epidemiology | |
| dc.subject | musculoskeletal | |
| dc.subject | pain | |
| dc.subject | population health | |
| dc.title | Association of Biomarkers with Individual and Multiple Body Sites of Pain: The Johnston County Osteoarthritis Project. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Norman, Katherine S|0000-0002-3064-5294 | |
| duke.contributor.orcid | Goode, Adam P|0000-0002-0793-3298 | |
| duke.contributor.orcid | George, Steven Z|0000-0003-4988-9421 | |
| duke.contributor.orcid | Fillipo, Rebecca|0000-0003-1467-7971 | |
| duke.contributor.orcid | Kraus, Virginia B|0000-0001-8173-8258 | |
| pubs.begin-page | 2393 | |
| pubs.end-page | 2404 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Student | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Orthopaedic Surgery | |
| pubs.organisational-group | Pathology | |
| pubs.organisational-group | Medicine, Rheumatology and Immunology | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.organisational-group | Duke Molecular Physiology Institute | |
| pubs.organisational-group | Orthopaedic Surgery, Physical Therapy | |
| pubs.organisational-group | Population Health Sciences | |
| pubs.organisational-group | Regeneration Next Initiative | |
| pubs.publication-status | Published | |
| pubs.volume | 15 |
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