Host genetics and HIV-1: the final phase?

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This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral load or disease progression. Results from other studies that used various large-scale approaches (siRNA screens, transcriptome or proteome analysis, comparative genomics) have also shed new light on retroviral pathogenesis. However, most of the inter-individual variability in response to HIV-1 infection remains to be explained: genome resequencing and systems biology approaches are now required to progress toward a better understanding of the complex interactions between HIV-1 and its human host.





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Fellay, Jacques, Kevin V Shianna, Amalio Telenti and David B Goldstein (2010). Host genetics and HIV-1: the final phase?. PLoS Pathog, 6(10). p. e1001033. 10.1371/journal.ppat.1001033 Retrieved from

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