Incontinence and gait disturbance after intraventricular extension of intracerebral hemorrhage.

Woo, Daniel

Kruger, Andrew J

Sekar, Padmini

Haverbusch, Mary

Osborne, Jennifer

Moomaw, Charles J

Martini, Sharyl

Hosseini, Shahla M

Ferioli, Simona

Worrall, Bradford B

Elkind, Mitchell SV

Sung, Gene

James, Michael L

Testai, Fernando D

Langefeld, Carl D

Broderick, Joseph P

Koch, Sebastian

Flaherty, Matthew L

United States

2016-03-01T14:38:06Z

2016-03-08

OBJECTIVE: We tested the hypothesis that intraventricular hemorrhage (IVH) is associated with incontinence and gait disturbance among survivors of intracerebral hemorrhage (ICH) at 3-month follow-ups. METHODS: The Genetic and Environmental Risk Factors for Hemorrhagic Stroke study was used as the discovery set. The Ethnic/Racial Variations of Intracerebral Hemorrhage study served as a replication set. Both studies performed prospective hot-pursuit recruitment of ICH cases with 3-month follow-up. Multivariable logistic regression analyses were computed to identify risk factors for incontinence and gait dysmobility at 3 months after ICH. RESULTS: The study population consisted of 307 ICH cases in the discovery set and 1,374 cases in the replication set. In the discovery set, we found that increasing IVH volume was associated with incontinence (odds ratio [OR] 1.50; 95% confidence interval [CI] 1.10-2.06) and dysmobility (OR 1.58; 95% CI 1.17-2.15) after controlling for ICH location, initial ICH volume, age, baseline modified Rankin Scale score, sex, and admission Glasgow Coma Scale score. In the replication set, increasing IVH volume was also associated with both incontinence (OR 1.42; 95% CI 1.27-1.60) and dysmobility (OR 1.40; 95% CI 1.24-1.57) after controlling for the same variables. CONCLUSION: ICH subjects with IVH extension are at an increased risk for developing incontinence and dysmobility after controlling for factors associated with severity and disability. This finding suggests a potential target to prevent or treat long-term disability after ICH with IVH.

http://www.ncbi.nlm.nih.gov/pubmed/26850978

WNL.0000000000002449

1526-632X

https://hdl.handle.net/10161/11669

eng

Ovid Technologies (Wolters Kluwer Health)

Neurology

10.1212/WNL.0000000000002449

Aged

Aged, 80 and over

Case-Control Studies

Cerebral Hemorrhage

Cerebral Ventricles

Cohort Studies

Female

Follow-Up Studies

Gait Disorders, Neurologic

Humans

Male

Middle Aged

Prospective Studies

Treatment Outcome

Urinary Incontinence

Incontinence and gait disturbance after intraventricular extension of intracerebral hemorrhage.

Journal article

James, Michael L|0000-0002-8715-5210

http://www.ncbi.nlm.nih.gov/pubmed/26850978

905

911

10

Anesthesiology

Anesthesiology, Neuroanesthesia

Clinical Science Departments

Duke

Neurology

Neurology, Neurocritical Care

School of Medicine

Published

86