Genetic variants of PDGF signaling pathway genes predict cutaneous melanoma survival.

dc.contributor.author

Li, Hong

dc.contributor.author

Wang, Yanru

dc.contributor.author

Liu, Hongliang

dc.contributor.author

Shi, Qiong

dc.contributor.author

Li, Hongyu

dc.contributor.author

Wu, Wenting

dc.contributor.author

Zhu, Dakai

dc.contributor.author

Amos, Christopher I

dc.contributor.author

Fang, Shenying

dc.contributor.author

Lee, Jeffrey E

dc.contributor.author

Li, Yi

dc.contributor.author

Han, Jiali

dc.contributor.author

Wei, Qingyi

dc.date.accessioned

2021-07-08T15:53:52Z

dc.date.available

2021-07-08T15:53:52Z

dc.date.issued

2017-09

dc.date.updated

2021-07-08T15:53:51Z

dc.description.abstract

To investigate whether genetic variants of platelet-derived growth factor (PDGF) signaling pathway genes are associated with survival of cutaneous melanoma (CM) patients, we assessed associations of single-nucleotide polymorphisms in PDGF pathway with melanoma-specific survival in 858 CM patients of M.D. Anderson Cancer Center (MDACC). Additional data of 409 cases from Harvard University were also included for further analysis. We identified 13 SNPs in four genes (COL6A3, NCK2, COL5A1 and PRKCD) with a nominal P < 0.05 and false discovery rate (FDR) < 0.2 in MDACC dataset. Based on linkage disequilibrium, functional prediction and minor allele frequency, a representative SNP in each gene was selected. In the meta-analysis using MDACC and Harvard datasets, there were two SNPs associated with poor survival of CM patients: rs6707820 C>T in NCK2 (HR = 1.87, 95% CI = 1.35-2.59, Pmeta= 1.53E-5); and rs2306574 T>C in PRKCD (HR = 1.73, 95% CI = 1.33-2.24, Pmeta= 4.56E-6). Moreover, CM patients in MDACC with combined risk genotypes of these two loci had markedly poorer survival (HR = 2.47, 95% CI = 1.58-3.84, P < 0.001). Genetic variants of rs6707820 C>T in NCK2 and rs2306574 T>C in PRKCD of the PDGF signaling pathway may be biomarkers for melanoma survival.

dc.identifier

20245

dc.identifier.issn

1949-2553

dc.identifier.issn

1949-2553

dc.identifier.uri

https://hdl.handle.net/10161/23442

dc.language

eng

dc.publisher

Impact Journals, LLC

dc.relation.ispartof

Oncotarget

dc.relation.isversionof

10.18632/oncotarget.20245

dc.subject

Cox regression

dc.subject

PDGF signaling pathway

dc.subject

cutaneous melanoma

dc.subject

single nucleotide polymorphisms

dc.title

Genetic variants of PDGF signaling pathway genes predict cutaneous melanoma survival.

dc.type

Journal article

duke.contributor.orcid

Wei, Qingyi|0000-0002-3845-9445

pubs.begin-page

74595

pubs.end-page

74606

pubs.issue

43

pubs.organisational-group

School of Medicine

pubs.organisational-group

Duke Cancer Institute

pubs.organisational-group

Population Health Sciences

pubs.organisational-group

Duke Global Health Institute

pubs.organisational-group

Medicine, Medical Oncology

pubs.organisational-group

Duke

pubs.organisational-group

Institutes and Centers

pubs.organisational-group

Basic Science Departments

pubs.organisational-group

University Institutes and Centers

pubs.organisational-group

Institutes and Provost's Academic Units

pubs.organisational-group

Medicine

pubs.organisational-group

Clinical Science Departments

pubs.publication-status

Published

pubs.volume

8

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Genetic variants of PDGF signaling pathway genes predict cutaneous melanoma survival.pdf
Size:
2.83 MB
Format:
Adobe Portable Document Format