Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage.
| dc.contributor.author | Sheng, Siyuan P | |
| dc.contributor.author | Lei, Beilei | |
| dc.contributor.author | James, Michael L | |
| dc.contributor.author | Lascola, Christopher D | |
| dc.contributor.author | Venkatraman, Talaignair N | |
| dc.contributor.author | Jung, Jin Yong | |
| dc.contributor.author | Maze, Mervyn | |
| dc.contributor.author | Franks, Nicholas P | |
| dc.contributor.author | Pearlstein, Robert D | |
| dc.contributor.author | Sheng, Huaxin | |
| dc.contributor.author | Warner, David S | |
| dc.date.accessioned | 2021-06-01T14:13:41Z | |
| dc.date.available | 2021-06-01T14:13:41Z | |
| dc.date.issued | 2012-12 | |
| dc.date.updated | 2021-06-01T14:13:41Z | |
| dc.description.abstract | BackgroundXenon has been proven to be neuroprotective in experimental brain injury. The authors hypothesized that xenon would improve outcome from focal cerebral ischemia with a delayed treatment onset and prolonged recovery interval.MethodsRats were subjected to 70 min temporary focal ischemia. Ninety minutes later, rats were treated with 0, 15, 30, or 45% Xe for 20 h or 0 or 30% Xe for 8, 20, or 44 h. Outcome was measured after 7 days. In another experiment, after ischemia, rats were maintained at 37.5° or 36.0°C for 20 h with or without 30% Xe. Outcome was assessed 28 days later. Finally, mice were subjected to intracerebral hemorrhage with or without 30% Xe for 20 h. Brain water content, hematoma volume, rotarod function, and microglial activation were measured.ResultsCerebral infarct sizes (mean±SD) for 0, 15, 30, and 45% Xe were 212±27, 176±55, 160±32, and 198±54 mm, respectively (P=0.023). Neurologic scores (median±interquartile range) followed a similar pattern (P=0.002). Infarct size did not vary with treatment duration, but neurologic score improved (P=0.002) at all xenon exposure durations (8, 20, and 44 h). Postischemic treatment with either 30% Xe or subtherapeutic hypothermia (36°C) had no effect on 28-day outcome. Combination of these interventions provided long-term benefit. Xenon improved intracerebral hemorrhage outcome measures.ConclusionXenon improved focal ischemic outcome at 7, but not 28 days postischemia. Xenon combined with subtherapeutic hypothermia produced sustained recovery benefit. Xenon improved intracerebral hemorrhage outcome. Xenon may have potential for clinical stroke therapy under carefully defined conditions. | |
| dc.identifier.issn | 0003-3022 | |
| dc.identifier.issn | 1528-1175 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Ovid Technologies (Wolters Kluwer Health) | |
| dc.relation.ispartof | Anesthesiology | |
| dc.relation.isversionof | 10.1097/aln.0b013e3182746b81 | |
| dc.subject | Animals | |
| dc.subject | Mice, Inbred C57BL | |
| dc.subject | Mice | |
| dc.subject | Rats | |
| dc.subject | Rats, Wistar | |
| dc.subject | Cerebral Hemorrhage | |
| dc.subject | Disease Models, Animal | |
| dc.subject | Xenon | |
| dc.subject | Neuroprotective Agents | |
| dc.subject | Hypothermia, Induced | |
| dc.subject | Pilot Projects | |
| dc.subject | Random Allocation | |
| dc.subject | Male | |
| dc.subject | Stroke | |
| dc.title | Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage. | |
| dc.type | Journal article | |
| duke.contributor.orcid | James, Michael L|0000-0002-8715-5210 | |
| duke.contributor.orcid | Lascola, Christopher D|0000-0002-8031-782X | |
| duke.contributor.orcid | Sheng, Huaxin|0000-0002-4325-2940 | |
| pubs.begin-page | 1262 | |
| pubs.end-page | 1275 | |
| pubs.issue | 6 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.organisational-group | Neurology, Neurocritical Care | |
| pubs.organisational-group | Anesthesiology, Neuroanesthesia | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Neurology | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Anesthesiology | |
| pubs.organisational-group | Duke-UNC Center for Brain Imaging and Analysis | |
| pubs.organisational-group | Neurobiology | |
| pubs.organisational-group | Radiology, Neuroradiology | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Radiology | |
| pubs.organisational-group | Neurosurgery | |
| pubs.organisational-group | Duke Institute for Brain Sciences | |
| pubs.organisational-group | Surgery | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.publication-status | Published | |
| pubs.volume | 117 |