Next-Generation Vaccine Development with Nanomaterials: Recent Advances, Possibilities, and Challenges.
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2024-07
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Nanomaterials are becoming important tools for vaccine development owing to their tunable and adaptable nature. Unique properties of nanomaterials afford opportunities to modulate trafficking through various tissues, complement or augment adjuvant activities, and specify antigen valency and display. This versatility has enabled recent work designing nanomaterial vaccines for a broad range of diseases, including cancer, inflammatory diseases, and various infectious diseases. Recent successes of nanoparticle vaccines during the coronavirus disease 2019 (COVID-19) pandemic have fueled enthusiasm further. In this review, the most recent developments in nanovaccines for infectious disease, cancer, inflammatory diseases, allergic diseases, and nanoadjuvants are summarized. Additionally, challenges and opportunities for clinical translation of this unique class of materials are discussed.
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Shetty, Shamitha, Pablo Cordero Alvarado, Deleah Pettie and Joel H Collier (2024). Next-Generation Vaccine Development with Nanomaterials: Recent Advances, Possibilities, and Challenges. Annual review of biomedical engineering, 26(1). pp. 273–306. 10.1146/annurev-bioeng-110122-124359 Retrieved from https://hdl.handle.net/10161/31656.
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Scholars@Duke
Shamitha Shetty
Joel Collier
The Collier Lab designs biomaterials for a range of biomedical applications, with a focus on understanding and controlling adaptive immune responses. Most materials investigated are created from molecular assemblies- proteins, peptides or bioconjugates that self-organize into useful structures such as nanofibers, gels, and particles.
These biomaterials are being developed as novel treatments for infectious diseases, cancer, wound healing, and chronic inflammation. Additionally, as these strategies are developed, basic insights into how materials engage the immune system are uncovered.
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