Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study.

Eichenberger, Emily M

Ruffin, Felicia

Dagher, Michael

Lerebours, Reginald

Jung, Sin-Ho

Sharma-Kuinkel, Batu

Macintyre, Andrew N

Thaden, Joshua T

Sinclair, Matthew

Hale, Lauren

Kohler, Celia

Palmer, Scott M

Alexander, Barbara D

Fowler, Vance G

Maskarinec, Stacey A

2022-02-01T20:02:06Z

2022-02-01T20:02:06Z

2021-06

2022-02-01T20:02:05Z

We undertook a prospective, matched cohort study of patients with Staphylococcus aureus bacteremia (SAB) and gram-negative bacteremia (GNB) to compare the characteristics, outcomes, and chemokine and cytokine response in transplant recipients to immunocompetent, nontransplant recipients. Fifty-five transplant recipients (GNB n = 29; SAB n = 26) and 225 nontransplant recipients (GNB n = 114; SAB n = 111) were included for clinical analysis. Transplant GNB had a significantly lower incidence of septic shock than nontransplant GNB (10.3% vs 30.7%, p = .03). Thirty-day mortality did not differ significantly between transplant and nontransplant recipients with GNB (10.3% vs 15.8%, p = .57) or SAB (0.0% vs 11.7%, p = .13). Next, transplant patients were matched 1:1 with nontransplant patients for the chemokine and cytokine analysis. Five cytokines and chemokines were significantly lower in transplant GNB vs nontransplant GNB: IL-2 (median [IQR]: 7.1 pg/ml [7.1, 7.1] vs 32.6 pg/ml [7.1, 88.0]; p = .001), MIP-1β (30.7 pg/ml [30.7, 30.7] vs 243.3 pg/ml [30.7, 344.4]; p = .001), IL-8 (32.0 pg/ml [5.6, 53.1] vs 59.1 pg/ml [39.2, 119.4]; p = .003), IL-15 (12.0 pg/ml [12.0, 12.0] vs 12.0 pg/ml [12.0, 126.7]; p = .03), and IFN-α (5.1 pg/mL [5.1, 5.1] vs 5.1 pg/ml [5.1, 26.3]; p = .04). Regulated upon Activation, Normal T Cell Expressed and Secreted (RANTES) was higher in transplant SAB vs nontransplant SAB (mean [SD]: 750.2 pg/ml [194.6] vs 656.5 pg/ml [147.6]; p = .046).

1600-6135

1600-6143

https://hdl.handle.net/10161/24331

eng

Elsevier BV

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

10.1111/ajt.16388

Humans

Bacteremia

Cytokines

Organ Transplantation

Cohort Studies

Prospective Studies

Transplant Recipients

Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study.

Journal article

Eichenberger, Emily M|0000-0002-2469-0638

Ruffin, Felicia|0000-0003-2176-6462

Lerebours, Reginald|0000-0003-2884-3168

Jung, Sin-Ho|0000-0002-1473-7236

Macintyre, Andrew N|0000-0002-5297-0207

Thaden, Joshua T|0000-0002-3250-0697

Sinclair, Matthew|0000-0002-8003-9786

Palmer, Scott M|0000-0002-1370-3771

Alexander, Barbara D|0000-0001-5868-0529

Fowler, Vance G|0000-0002-8048-0897

2113

2122

6

Duke

School of Medicine

Staff

Basic Science Departments

Clinical Science Departments

Institutes and Centers

Biostatistics & Bioinformatics

Immunology

Molecular Genetics and Microbiology

Medicine

Pathology

Medicine, Duke Human Vaccine Institute

Medicine, Infectious Diseases

Medicine, Pulmonary, Allergy, and Critical Care Medicine

Duke Cancer Institute

Duke Clinical Research Institute

Institutes and Provost's Academic Units

Initiatives

Population Health Sciences

Duke Innovation & Entrepreneurship

Published

21