Cross-Reactive Dengue Virus Antibodies Augment Zika Virus Infection of Human Placental Macrophages.
| dc.contributor.author | Zimmerman, Matthew G | |
| dc.contributor.author | Quicke, Kendra M | |
| dc.contributor.author | O'Neal, Justin T | |
| dc.contributor.author | Arora, Nitin | |
| dc.contributor.author | Machiah, Deepa | |
| dc.contributor.author | Priyamvada, Lalita | |
| dc.contributor.author | Kauffman, Robert C | |
| dc.contributor.author | Register, Emery | |
| dc.contributor.author | Adekunle, Oluwaseyi | |
| dc.contributor.author | Swieboda, Dominika | |
| dc.contributor.author | Johnson, Erica L | |
| dc.contributor.author | Cordes, Sarah | |
| dc.contributor.author | Haddad, Lisa | |
| dc.contributor.author | Chakraborty, Rana | |
| dc.contributor.author | Coyne, Carolyn B | |
| dc.contributor.author | Wrammert, Jens | |
| dc.contributor.author | Suthar, Mehul S | |
| dc.date.accessioned | 2021-04-16T19:55:32Z | |
| dc.date.available | 2021-04-16T19:55:32Z | |
| dc.date.issued | 2018-11 | |
| dc.date.updated | 2021-04-16T19:55:27Z | |
| dc.description.abstract | Zika virus (ZIKV), which emerged in regions endemic to dengue virus (DENV), is vertically transmitted and results in adverse pregnancy outcomes. Antibodies to DENV can cross-react with ZIKV, but whether these antibodies influence ZIKV vertical transmission remains unclear. Here, we find that DENV antibodies increase ZIKV infection of placental macrophages (Hofbauer cells [HCs]) from 10% to over 80% and enhance infection of human placental explants. ZIKV-anti-DENV antibody complexes increase viral binding and entry into HCs but also result in blunted type I interferon, pro-inflammatory cytokine, and antiviral responses. Additionally, ZIKV infection of HCs and human placental explants is enhanced in an immunoglobulin G subclass-dependent manner, and targeting FcRn reduces ZIKV replication in human placental explants. Collectively, these findings support a role for pre-existing DENV antibodies in enhancement of ZIKV infection of select placental cell types and indicate that pre-existing immunity to DENV should be considered when addressing ZIKV vertical transmission. | |
| dc.identifier | S1931-3128(18)30546-8 | |
| dc.identifier.issn | 1931-3128 | |
| dc.identifier.issn | 1934-6069 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Elsevier BV | |
| dc.relation.ispartof | Cell host & microbe | |
| dc.relation.isversionof | 10.1016/j.chom.2018.10.008 | |
| dc.subject | Chorionic Villi | |
| dc.subject | Macrophages | |
| dc.subject | Placenta | |
| dc.subject | Humans | |
| dc.subject | Dengue Virus | |
| dc.subject | Dengue | |
| dc.subject | Immunoglobulin G | |
| dc.subject | Interferon Type I | |
| dc.subject | Antibodies, Monoclonal | |
| dc.subject | Antibodies, Viral | |
| dc.subject | Cytokines | |
| dc.subject | Antibody-Dependent Enhancement | |
| dc.subject | Cross Reactions | |
| dc.subject | Gene Expression | |
| dc.subject | Pregnancy | |
| dc.subject | Female | |
| dc.subject | Virus Internalization | |
| dc.subject | Infectious Disease Transmission, Vertical | |
| dc.subject | Antibodies, Neutralizing | |
| dc.subject | Zika Virus | |
| dc.subject | Zika Virus Infection | |
| dc.title | Cross-Reactive Dengue Virus Antibodies Augment Zika Virus Infection of Human Placental Macrophages. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Coyne, Carolyn B|0000-0002-1884-6309 | |
| pubs.begin-page | 731 | |
| pubs.end-page | 742.e6 | |
| pubs.issue | 5 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Molecular Genetics and Microbiology | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.publication-status | Published | |
| pubs.volume | 24 |
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