Relationship of physical function with quality of life in older patients with acute heart failure.

dc.contributor.author

Aladin, Amer I

dc.contributor.author

Whellan, David

dc.contributor.author

Mentz, Robert J

dc.contributor.author

Pastva, Amy M

dc.contributor.author

Nelson, M Benjamin

dc.contributor.author

Brubaker, Peter

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Duncan, Pamela

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Reeves, Gordon

dc.contributor.author

Rosenberg, Paul

dc.contributor.author

Kitzman, Dalane W

dc.date.accessioned

2024-02-02T17:31:05Z

dc.date.available

2024-02-02T17:31:05Z

dc.date.issued

2021-07

dc.description.abstract

Background

Older patients with acute decompensated heart failure (ADHF) have severely impaired physical function (PF) and quality of life (QOL). However, relationships between impairments in PF and QOL are unknown but are relevant to clinical practice and trial design.

Methods

We assessed 202 consecutive patients hospitalized with ADHF in the multicenter Rehabilitation Therapy in Older Acute HF Patients (REHAB-HF) Trial. PF measures included Short Physical Performance Battery (SPPB) and 6-min walk distance (6MWD). Disease-specific QOL was assessed by the Kansas City Cardiomyopathy Questionnaire (KCCQ). General QOL was assessed by the Short Form-12 (SF-12) and EuroQol-5D-5L. PF was evaluated as a predictor of QOL using stepwise regression adjusted for age, sex, race, and New York Heart Association class.

Results

Participants were 72 ± 8 years, 54% women, 55% minority race, 52% with reduced ejection fraction, and body mass index 33 ± 9 kg/m2 . Participants had severe impairments in PF (6MWD 185 ± 99 m, SPPB 6.0 ± 2.5 units) and disease-specific QOL (KCCQ Overall Score 41 ± 21 and Physical Score 47 ± 24) and general QOL (SF-12 Physical Score 28 ± 9 and EuroQol Visual Analog Scale 57 ± 23). There were modest, statistically significant correlations between 6MWD and KCCQ Overall, KCCQ Physical Limitation, and SF-12 Physical Scores (r = 0.23, p < 0.001; r = 0.30, p < 0.001; and r = 0.24, p = 0.001, respectively); and between SPPB and KCCQ Physical and SF-12 Physical Scores (r = 0.20, p = 0.004, and r = 0.19, p = 0.007, respectively). Both 6MWD and SPPB were correlated with multiple components of the EuroQol-5D-5L. 6MWD was a significant, weak predictor of KCCQ Overall Score and SF-12 Physical Score (estimate = 0.05 ± 0.01, p < 0.001 and estimate = 0.05 ± 0.02, p = 0.012, respectively). SPPB was a significant, weak predictor of KCCQ Physical Score and SF-12 Physical Score (estimate = 1.37 ± 0.66, p = 0.040 and estimate = 0.54 ± 0.25, p = 0.030, respectively).

Conclusion

In older, hospitalized ADHF patients, PF and QOL are both severely impaired but are only modestly related, suggesting that PF and QOL provide complementary information and assessment of both should be considered to fully assess clinically meaningful patient-oriented outcomes.
dc.identifier.issn

0002-8614

dc.identifier.issn

1532-5415

dc.identifier.uri

https://hdl.handle.net/10161/30119

dc.language

eng

dc.publisher

Wiley

dc.relation.ispartof

Journal of the American Geriatrics Society

dc.relation.isversionof

10.1111/jgs.17156

dc.rights.uri

https://creativecommons.org/licenses/by-nc/4.0

dc.subject

Humans

dc.subject

Acute Disease

dc.subject

Stroke Volume

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Body Mass Index

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Regression Analysis

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Quality of Life

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Aged

dc.subject

Aged, 80 and over

dc.subject

Inpatients

dc.subject

Female

dc.subject

Male

dc.subject

Heart Failure

dc.subject

Walk Test

dc.subject

Functional Status

dc.title

Relationship of physical function with quality of life in older patients with acute heart failure.

dc.type

Journal article

duke.contributor.orcid

Mentz, Robert J|0000-0002-3222-1719

duke.contributor.orcid

Pastva, Amy M|0000-0002-0891-745X

duke.contributor.orcid

Rosenberg, Paul|0000-0002-5659-160X

pubs.begin-page

1836

pubs.end-page

1845

pubs.issue

7

pubs.organisational-group

Duke

pubs.organisational-group

School of Medicine

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Basic Science Departments

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Clinical Science Departments

pubs.organisational-group

Institutes and Centers

pubs.organisational-group

Cell Biology

pubs.organisational-group

Medicine

pubs.organisational-group

Orthopaedic Surgery

pubs.organisational-group

Pathology

pubs.organisational-group

Medicine, Cardiology

pubs.organisational-group

Medicine, Pulmonary, Allergy, and Critical Care Medicine

pubs.organisational-group

Duke Cancer Institute

pubs.organisational-group

Duke Clinical Research Institute

pubs.organisational-group

Duke Molecular Physiology Institute

pubs.organisational-group

Orthopaedic Surgery, Physical Therapy

pubs.organisational-group

Population Health Sciences

pubs.publication-status

Published

pubs.volume

69

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