Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial.

Albert, Dustin

Belsky, Daniel W

Crowley, D Max

Latendresse, Shawn J

Aliev, Fazil

Riley, Brien

Group, Conduct Problems Prevention Research

Dick, Danielle M

Dodge, Kenneth A

United States

2015-01-15T19:59:56Z

2015

Early interventions are a preferred method for addressing behavioral problems in high-risk children, but often have only modest effects. Identifying sources of variation in intervention effects can suggest means to improve efficiency. One potential source of such variation is the genome. We conducted a genetic analysis of the Fast Track randomized control trial, a 10-year-long intervention to prevent high-risk kindergarteners from developing adult externalizing problems including substance abuse and antisocial behavior. We tested whether variants of the glucocorticoid receptor gene NR3C1 were associated with differences in response to the Fast Track intervention. We found that in European-American children, a variant of NR3C1 identified by the single-nucleotide polymorphism rs10482672 was associated with increased risk for externalizing psychopathology in control group children and decreased risk for externalizing psychopathology in intervention group children. Variation in NR3C1 measured in this study was not associated with differential intervention response in African-American children. We discuss implications for efforts to prevent externalizing problems in high-risk children and for public policy in the genomic era.

http://www.ncbi.nlm.nih.gov/pubmed/26106668

0276-8739

https://hdl.handle.net/10161/9365

eng

Wiley

J Policy Anal Manage

Adult

Antisocial Personality Disorder

Behavior Therapy

Child

Child Behavior Disorders

Early Medical Intervention

Genetic Variation

Genome, Human

Humans

Internal-External Control

Polymorphism, Single Nucleotide

Psychopathology

Randomized Controlled Trials as Topic

Receptors, Glucocorticoid

Substance-Related Disorders

Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial.

Journal article

Belsky, Daniel W|0000-0001-5463-2212

Dodge, Kenneth A|0000-0001-5932-215X

http://www.ncbi.nlm.nih.gov/pubmed/26106668

497

518

3

Center for Child and Family Policy

Center for the Study of Aging and Human Development

Clinical Science Departments

Duke

Duke Institute for Brain Sciences

Duke Population Research Center

Duke Population Research Institute

Duke Science & Society

Initiatives

Institutes and Centers

Institutes and Provost's Academic Units

Medicine

Medicine, Geriatrics

Psychiatry, Child & Family Mental Health and Developmental Neuroscience

Psychiatry & Behavioral Sciences

Psychology and Neuroscience

Sanford School of Public Policy

Sanford School of Public Policy - Secondary Group

School of Medicine

Social Science Research Institute

Staff

Trinity College of Arts & Sciences

University Institutes and Centers

Published

34