Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort.

Hoyo, Cathrine

Daltveit, Anne Kjersti

Iversen, Edwin

Benjamin-Neelon, Sara E

Fuemmeler, Bernard

Schildkraut, Joellen

Murtha, Amy P

Overcash, Francine

Vidal, Adriana C

Wang, Frances

Huang, Zhiqing

Kurtzberg, Joanne

Seewaldt, Victoria

Forman, Michele

Jirtle, Randy L

Murphy, Susan K

2022-03-23T19:30:33Z

2022-03-23T19:30:33Z

2014-08

2022-03-23T19:30:32Z

Epigenetic mechanisms are proposed to link maternal concentrations of methyl group donor nutrients with the risk of low birth weight. However, empirical data are lacking. We have examined the association between maternal folate and birth weight and assessed the mediating role of DNA methylation at nine differentially methylated regions (DMRs) of genomically imprinted genes in these associations. Compared with newborns of women with folate levels in the lowest quartile, birth weight was higher in newborns of mothers in the second (β = 143.2, se = 63.2, P = 0.02), third (β = 117.3, se = 64.0, P = 0.07), and fourth (β = 133.9, se = 65.2, P = 0.04) quartiles, consistent with a threshold effect. This pattern of association did not vary by race/ethnicity but was more apparent in newborns of non-obese women. DNA methylation at the PLAGL1, SGCE, DLK1/MEG3 and IGF2/H19 DMRs was associated with maternal folate levels and also birth weight, suggestive of threshold effects. MEG3 DMR methylation mediated the association between maternal folate levels and birth weight (P =0.06). While the small sample size and partial scope of examined DMRs limit our conclusions, our data suggest that, with respect to birth weight, no additional benefits may be derived from increased maternal folate concentrations, especially in non-obese women. These data also support epigenetic plasticity as a key mechanistic response to folate availability during early fetal development.

29332

1559-2294

1559-2308

https://hdl.handle.net/10161/24655

eng

Informa UK Limited

Epigenetics

10.4161/epi.29332

Erythrocytes

Humans

Birth Weight

Folic Acid

Cohort Studies

DNA Methylation

Epigenesis, Genetic

Genomic Imprinting

CpG Islands

Pregnancy

Adolescent

Adult

Infant, Newborn

Continental Population Groups

Ethnic Groups

Female

Male

Young Adult

Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort.

Journal article

Kurtzberg, Joanne|0000-0002-3370-0703

Murphy, Susan K|0000-0001-8298-7272

1120

1130

8

Duke

Nicholas School of the Environment

Sanford School of Public Policy

School of Medicine

Trinity College of Arts & Sciences

Faculty

Clinical Science Departments

Institutes and Centers

Family Medicine and Community Health

Pathology

Pediatrics

Family Medicine and Community Health, Prevention Research

Pediatrics, Primary Care Pediatrics

Duke Cancer Institute

Statistical Science

Environmental Sciences and Policy

Institutes and Provost's Academic Units

Initiatives

Center for Child and Family Policy

Duke Innovation & Entrepreneurship

Pediatrics, Transplant and Cellular Therapy

Published

9