Perioperative Outcomes After Bioprosthetic Valve Replacement in Patients Sensitized to Alpha-Gal.
dc.contributor.author | Aykut, Berk | |
dc.contributor.author | Lim, Hoe King | |
dc.contributor.author | Ngeve, Smith M | |
dc.contributor.author | Hoover, Anna | |
dc.contributor.author | Medina, Cathlyn K | |
dc.contributor.author | Scherba, Jacob | |
dc.contributor.author | Menken, Ashley | |
dc.contributor.author | Overbey, Douglas M | |
dc.contributor.author | Omer, Tariq M | |
dc.contributor.author | Commins, Scott P | |
dc.contributor.author | Nellis, Joseph R | |
dc.contributor.author | Turek, Joseph W | |
dc.date.accessioned | 2025-07-01T16:51:24Z | |
dc.date.available | 2025-07-01T16:51:24Z | |
dc.date.issued | 2025-03 | |
dc.description.abstract | BackgroundAlpha-gal syndrome from tick bites, due to sensitivity to alpha-gal, can cause severe allergies. Heart valve implants contain alpha-gal, yet alpha-gal syndrome screening is not standard before valve replacement. This study examines perioperative outcomes in patients with alpha-gal antibodies.MethodsThis is a single-institution prospective cohort study of patients undergoing bioprosthetic aortic valve replacement between January 2022 and January 2023. Anti-alpha-gal immunoglobulin E levels were measured, with primary outcomes being severe allergic reactions and in-hospital mortality, and secondary outcomes including intensive care unit and hospital stay.ResultsOf 155 patients, 32.7% (n = 19) of surgical aortic valve replacement and 29.9% (n = 29) of transcatheter aortic valve replacement patients had detectable immunoglobulin E levels without subsequent serious allergic reactions or in-hospital mortality. Postoperative hospital stay and valve function were similar across groups.ConclusionsIn this study, sensitization to alpha-gal was not associated with serious allergic reactions and did not affect immediate aortic valve function after surgical aortic valve replacement or transcatheter aortic valve replacement. | |
dc.identifier | S2772-9931(24)00324-3 | |
dc.identifier.issn | 2772-9931 | |
dc.identifier.issn | 2772-9931 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Elsevier BV | |
dc.relation.ispartof | Annals of thoracic surgery short reports | |
dc.relation.isversionof | 10.1016/j.atssr.2024.07.012 | |
dc.rights.uri | ||
dc.title | Perioperative Outcomes After Bioprosthetic Valve Replacement in Patients Sensitized to Alpha-Gal. | |
dc.type | Journal article | |
duke.contributor.orcid | Turek, Joseph W|0000-0002-4006-7555 | |
pubs.begin-page | 264 | |
pubs.end-page | 268 | |
pubs.issue | 1 | |
pubs.organisational-group | Duke | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Pediatrics | |
pubs.organisational-group | Surgery | |
pubs.organisational-group | Surgery, Cardiovascular and Thoracic Surgery | |
pubs.publication-status | Published | |
pubs.volume | 3 |
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