Perioperative Outcomes After Bioprosthetic Valve Replacement in Patients Sensitized to Alpha-Gal.

dc.contributor.author

Aykut, Berk

dc.contributor.author

Lim, Hoe King

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Ngeve, Smith M

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Hoover, Anna

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Medina, Cathlyn K

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Scherba, Jacob

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Menken, Ashley

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Overbey, Douglas M

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Omer, Tariq M

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Commins, Scott P

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Nellis, Joseph R

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Turek, Joseph W

dc.date.accessioned

2025-07-01T16:51:24Z

dc.date.available

2025-07-01T16:51:24Z

dc.date.issued

2025-03

dc.description.abstract

Background

Alpha-gal syndrome from tick bites, due to sensitivity to alpha-gal, can cause severe allergies. Heart valve implants contain alpha-gal, yet alpha-gal syndrome screening is not standard before valve replacement. This study examines perioperative outcomes in patients with alpha-gal antibodies.

Methods

This is a single-institution prospective cohort study of patients undergoing bioprosthetic aortic valve replacement between January 2022 and January 2023. Anti-alpha-gal immunoglobulin E levels were measured, with primary outcomes being severe allergic reactions and in-hospital mortality, and secondary outcomes including intensive care unit and hospital stay.

Results

Of 155 patients, 32.7% (n = 19) of surgical aortic valve replacement and 29.9% (n = 29) of transcatheter aortic valve replacement patients had detectable immunoglobulin E levels without subsequent serious allergic reactions or in-hospital mortality. Postoperative hospital stay and valve function were similar across groups.

Conclusions

In this study, sensitization to alpha-gal was not associated with serious allergic reactions and did not affect immediate aortic valve function after surgical aortic valve replacement or transcatheter aortic valve replacement.
dc.identifier

S2772-9931(24)00324-3

dc.identifier.issn

2772-9931

dc.identifier.issn

2772-9931

dc.identifier.uri

https://hdl.handle.net/10161/32537

dc.language

eng

dc.publisher

Elsevier BV

dc.relation.ispartof

Annals of thoracic surgery short reports

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10.1016/j.atssr.2024.07.012

dc.rights.uri

https://creativecommons.org/licenses/by-nc/4.0

dc.title

Perioperative Outcomes After Bioprosthetic Valve Replacement in Patients Sensitized to Alpha-Gal.

dc.type

Journal article

duke.contributor.orcid

Turek, Joseph W|0000-0002-4006-7555

pubs.begin-page

264

pubs.end-page

268

pubs.issue

1

pubs.organisational-group

Duke

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School of Medicine

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Clinical Science Departments

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Pediatrics

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Surgery

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Surgery, Cardiovascular and Thoracic Surgery

pubs.publication-status

Published

pubs.volume

3

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