The role of extracellular matrix elasticity and composition in regulating the nucleus pulposus cell phenotype in the intervertebral disc: a narrative review.

dc.contributor.author

Hwang, Priscilla Y

dc.contributor.author

Chen, Jun

dc.contributor.author

Jing, Liufang

dc.contributor.author

Hoffman, Brenton D

dc.contributor.author

Setton, Lori A

dc.coverage.spatial

United States

dc.date.accessioned

2014-05-23T14:35:55Z

dc.date.issued

2014-02

dc.description.abstract

Intervertebral disc (IVD) disorders are a major contributor to disability and societal health care costs. Nucleus pulposus (NP) cells of the IVD exhibit changes in both phenotype and morphology with aging-related IVD degeneration that may impact the onset and progression of IVD pathology. Studies have demonstrated that immature NP cell interactions with their extracellular matrix (ECM) may be key regulators of cellular phenotype, metabolism and morphology. The objective of this article is to review our recent experience with studies of NP cell-ECM interactions that reveal how ECM cues can be manipulated to promote an immature NP cell phenotype and morphology. Findings demonstrate the importance of a soft (<700 Pa), laminin-containing ECM in regulating healthy, immature NP cells. Knowledge of NP cell-ECM interactions can be used for development of tissue engineering or cell delivery strategies to treat IVD-related disorders.

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/24390195

dc.identifier

1812596

dc.identifier.eissn

1528-8951

dc.identifier.uri

https://hdl.handle.net/10161/8879

dc.language

eng

dc.publisher

ASME International

dc.relation.ispartof

J Biomech Eng

dc.relation.isversionof

10.1115/1.4026360

dc.subject

Animals

dc.subject

Cell Differentiation

dc.subject

Computer Simulation

dc.subject

Elastic Modulus

dc.subject

Extracellular Matrix

dc.subject

Fibrillar Collagens

dc.subject

Fibrocartilage

dc.subject

Humans

dc.subject

Intervertebral Disc

dc.subject

Mechanotransduction, Cellular

dc.subject

Models, Biological

dc.subject

Stress, Mechanical

dc.title

The role of extracellular matrix elasticity and composition in regulating the nucleus pulposus cell phenotype in the intervertebral disc: a narrative review.

dc.type

Journal article

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/24390195

pubs.begin-page

021010

pubs.issue

2

pubs.organisational-group

Basic Science Departments

pubs.organisational-group

Biomedical Engineering

pubs.organisational-group

Cell Biology

pubs.organisational-group

Clinical Science Departments

pubs.organisational-group

Duke

pubs.organisational-group

Duke Institute for Brain Sciences

pubs.organisational-group

Institutes and Provost's Academic Units

pubs.organisational-group

Orthopaedics

pubs.organisational-group

Pratt School of Engineering

pubs.organisational-group

School of Medicine

pubs.organisational-group

University Institutes and Centers

pubs.publication-status

Published

pubs.volume

136

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
hwang_jbe.pdf
Size:
2.41 MB
Format:
Adobe Portable Document Format
Description:
Published version