Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer.

dc.contributor.author

Han, Chan H

dc.contributor.author

Huang, Yu-Jing

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Lu, Karen H

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Liu, Zhensheng

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Mills, Gordon B

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Wei, Qingyi

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Wang, Li-E

dc.date.accessioned

2019-02-01T15:25:46Z

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2019-02-01T15:25:46Z

dc.date.issued

2011-01-07

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2019-02-01T15:25:44Z

dc.description.abstract

SULF1 (sulfatase 1) selectively removes the 6-O-sulphate group from heparan sulfate, changing the binding sites for extracellular growth factors. SULF1 expression has been reported to be decreased in various cancers, including ovarian cancer. We hypothesized that single nucleotide polymorphisms (SNPs) of SULF1 would impact clinicopathologic characteristics.We genotyped five common (minor allele frequency>0.05) regulatory SNPs with predicted functionalities (rs2623047 G>A, rs13264163 A>G, rs6990375 G>A, rs3802278 G>A, and rs3087714 C>T) in 168 patients with primary epithelial ovarian cancer, using the polymerase chain reaction-restriction fragment length polymorphism method.We found that rs2623047 G>A was significantly associated with an early age of onset of ovarian cancer in the G allele dose-response manner (P = 0.027; Ptrend = 0.007) and that rs2623047 GG/GA genotypes were associated with longer progression-free survival; rs6990375 G>A was also associated with the early age of onset in the A allele dose-response manner (P = 0.013; Ptrend= 0.009). The significant differences in age of disease onset persisted among carriers of haplotypes of rs2623047 and rs6990375 (P = 0.014; Ptrend = 0.004). In luciferase reporter gene assays, rs2623047 G allele showed a slightly higher promoter activity than the A allele in the SKOV3 tumorigenic cell line.These findings suggest that genetic variations in SULF1 may play a role in ovarian cancer onset and prognosis. Further studies with large sample sizes and of the mechanistic relevance of SULF1 SNPs are warranted.

dc.identifier

1756-9966-30-5

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0392-9078

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1756-9966

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https://hdl.handle.net/10161/18017

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eng

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Springer Science and Business Media LLC

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Journal of experimental & clinical cancer research : CR

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10.1186/1756-9966-30-5

dc.subject

Humans

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Ovarian Neoplasms

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Sulfotransferases

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Neoplasm Staging

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Age of Onset

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Polymorphism, Single Nucleotide

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Aged

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Middle Aged

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Female

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Kaplan-Meier Estimate

dc.title

Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer.

dc.type

Journal article

duke.contributor.orcid

Wei, Qingyi|0000-0003-4115-4439|0000-0002-3845-9445

pubs.begin-page

5

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1

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Staff

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Duke

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School of Medicine

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Duke Cancer Institute

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Institutes and Centers

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Population Health Sciences

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Basic Science Departments

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Medicine, Medical Oncology

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Medicine

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Clinical Science Departments

pubs.publication-status

Published

pubs.volume

30

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