Modifying effect of mouse double minute-2 promoter variants on risk of recurrence for patients with squamous cell carcinoma of oropharynx.
| dc.contributor.author | Zhang, Yang | |
| dc.contributor.author | Sturgis, Erich M | |
| dc.contributor.author | Li, Yuncheng | |
| dc.contributor.author | Wei, Qingyi | |
| dc.contributor.author | Huang, Zhigang | |
| dc.contributor.author | Li, Guojun | |
| dc.date.accessioned | 2021-07-08T15:51:28Z | |
| dc.date.available | 2021-07-08T15:51:28Z | |
| dc.date.issued | 2017-01-03 | |
| dc.date.updated | 2021-07-08T15:51:27Z | |
| dc.description.abstract | Functional mouse double minute-2 (MDM2) promoter variants may alter MDM2 expression and thus affect radiotherapy response and prognosis of squamous cell carcinoma of oropharynx (SCCOP). Thus we assessed association of 2 functional MDM2 promoter variants with recurrence risk of SCCOP. The disease-free survival (DFS) of patients with MDM2rs2279744 TT or MDM2rs937283 AA genotypes was significantly reduced compared with that of patients with corresponding GT/GG or AG/GG genotypes. Multivariable analysis showed patients with TT or AA genotypes had a significantly higher risk of SCCOP recurrence than those with corresponding GT/GG or AG/GG genotypes did. Furthermore, patients with combined risk genotypes of the 2 polymorphisms had significantly worse DFS and a higher recurrence risk than patients with fewer combined risk genotypes did (Ptrend < 0.001). Compared with patients with 0 risk genotypes, patients with 1 or 2 risk genotypes had an approximately 3- or 11-fold increased risk of SCCOP recurrence, respectively. Notably, for both individual and combined polymorphisms, the above similar recurrence risks were particularly higher among patients with human papilloma virus (HPV)-positive tumors. Taken together, our findings suggest that MDM2 promoter variants individually, or more likely jointly, play a role in determining the risk of recurrence of SCCOP, particularly HPV-positive SCCOP. | |
| dc.identifier | srep39765 | |
| dc.identifier.issn | 2045-2322 | |
| dc.identifier.issn | 2045-2322 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Springer Science and Business Media LLC | |
| dc.relation.ispartof | Scientific reports | |
| dc.relation.isversionof | 10.1038/srep39765 | |
| dc.subject | Animals | |
| dc.subject | Humans | |
| dc.subject | Mice | |
| dc.subject | Papillomavirus Infections | |
| dc.subject | Carcinoma, Squamous Cell | |
| dc.subject | Head and Neck Neoplasms | |
| dc.subject | Oropharyngeal Neoplasms | |
| dc.subject | Neoplasm Recurrence, Local | |
| dc.subject | Risk | |
| dc.subject | Survival Analysis | |
| dc.subject | Follow-Up Studies | |
| dc.subject | Genotype | |
| dc.subject | Polymorphism, Single Nucleotide | |
| dc.subject | Middle Aged | |
| dc.subject | Female | |
| dc.subject | Male | |
| dc.subject | Proto-Oncogene Proteins c-mdm2 | |
| dc.subject | Human papillomavirus 16 | |
| dc.subject | Promoter Regions, Genetic | |
| dc.subject | Effect Modifier, Epidemiologic | |
| dc.subject | Squamous Cell Carcinoma of Head and Neck | |
| dc.title | Modifying effect of mouse double minute-2 promoter variants on risk of recurrence for patients with squamous cell carcinoma of oropharynx. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Wei, Qingyi|0000-0002-3845-9445 | |
| pubs.begin-page | 39765 | |
| pubs.issue | 1 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Population Health Sciences | |
| pubs.organisational-group | Duke Global Health Institute | |
| pubs.organisational-group | Medicine, Medical Oncology | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.publication-status | Published | |
| pubs.volume | 7 |
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