Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population.


Published data on the association between the MUC1 rs4072037A > G polymorphism and gastric cancer (GCa) risk were inconclusive. To derive a more precise estimation of the association, we conducted a large GCa study of 1,124 cases and 1,192 controls to confirm this association in an Eastern Chinese population. Our results showed that the G allele was strongly associated with a decreased GCa risk in the study population [GG vs. AA, odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.31-0.73; AG/GG vs. AA, OR = 0.82, 95% CI = 0.68-0.99; GG vs. AA/AG, OR = 0.48, 95% CI = 0.32-0.74]. These associations remained significant in subgroups of age, tumor site, drinking and smoking status. Moreover, this association was supported by an additional meta-analysis of published studies. In summary, these results suggest that the MUC1 rs4072037G allele may be a low-penetrating protection factor for GCa risk in Chinese populations.





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Publication Info

Qiu, Li-Xin, Rui-Xi Hua, Lei Cheng, Jing He, Meng-Yun Wang, Fei Zhou, Xiao-Dong Zhu, Meng-Hong Sun, et al. (2016). Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population. Oncotarget, 7(13). pp. 15930–15936. 10.18632/oncotarget.7527 Retrieved from

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