Host determinants of HIV-1 control in African Americans.
| dc.contributor.author | Pelak, Kimberly | |
| dc.contributor.author | Goldstein, David B | |
| dc.contributor.author | Walley, Nicole M | |
| dc.contributor.author | Fellay, Jacques | |
| dc.contributor.author | Ge, Dongliang | |
| dc.contributor.author | Shianna, Kevin V | |
| dc.contributor.author | Gumbs, Curtis | |
| dc.contributor.author | Gao, Xiaojiang | |
| dc.contributor.author | Maia, Jessica M | |
| dc.contributor.author | Cronin, Kenneth D | |
| dc.contributor.author | Hussain, Shehnaz K | |
| dc.contributor.author | Carrington, Mary | |
| dc.contributor.author | Michael, Nelson L | |
| dc.contributor.author | Weintrob, Amy C | |
| dc.contributor.author | Infectious Disease Clinical Research Program HIV Working Group | |
| dc.contributor.author | National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI) | |
| dc.coverage.spatial | United States | |
| dc.date.accessioned | 2011-06-21T17:27:21Z | |
| dc.date.issued | 2010-04-15 | |
| dc.description.abstract | We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 x 10(-10)). These analyses therefore confirm a member of the HLA-B57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701. | |
| dc.description.version | Version of Record | |
| dc.identifier | ||
| dc.identifier.eissn | 1537-6613 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.language.iso | en_US | |
| dc.publisher | Oxford University Press (OUP) | |
| dc.relation.ispartof | J Infect Dis | |
| dc.relation.isversionof | 10.1086/651382 | |
| dc.relation.journal | Journal of Infectious Diseases | |
| dc.subject | Adolescent | |
| dc.subject | Adult | |
| dc.subject | African Americans | |
| dc.subject | DNA-Binding Proteins | |
| dc.subject | Disease Progression | |
| dc.subject | Genome-Wide Association Study | |
| dc.subject | Genotype | |
| dc.subject | HIV Infections | |
| dc.subject | HIV-1 | |
| dc.subject | HLA-B Antigens | |
| dc.subject | HLA-C Antigens | |
| dc.subject | Humans | |
| dc.subject | Male | |
| dc.subject | Middle Aged | |
| dc.subject | Phenotype | |
| dc.subject | Polymorphism, Single Nucleotide | |
| dc.subject | Viral Load | |
| dc.subject | Young Adult | |
| dc.title | Host determinants of HIV-1 control in African Americans. | |
| dc.title.alternative | ||
| dc.type | Journal article | |
| duke.date.pubdate | 2010-4-15 | |
| duke.description.issue | 8 | |
| duke.description.volume | 201 | |
| pubs.author-url | ||
| pubs.begin-page | 1141 | |
| pubs.end-page | 1149 | |
| pubs.issue | 8 | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Duke Center for Human Genome Variation | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.organisational-group | Duke Institute for Brain Sciences | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | Molecular Genetics and Microbiology | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.publication-status | Published | |
| pubs.volume | 201 |