Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites.

dc.contributor.author

Guan, Xiaoxiang

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Wang, Li-E

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Liu, Zhensheng

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Sturgis, Erich M

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Wei, Qingyi

dc.date.accessioned

2019-02-01T15:27:50Z

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2019-02-01T15:27:50Z

dc.date.issued

2013-07

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2019-02-01T15:27:48Z

dc.description.abstract

Recently, several studies have investigated the association between a newly reported rare functional single nucleotide polymorphism (SNP) in TP53 (rs78378222) and cancer risk, but generated inconsistent findings. The present study further investigated this association with risk of melanoma, squamous cell carcinoma of head and neck (SCCHN) and lung cancer. Using volunteers of non-Hispanic Whites recruited for three large case-control studies, we genotyped the TP53 rs78378222 SNP in 1329 patients with melanoma, 1096 with SCCHN, 1013 with lung cancer and 3000 cancer-free controls. Overall, we did not observe any variant homozygotes in this study population, nor significant associations between the TP53 rs78378222AC genotype or C allele and risk for melanoma (P = 0.680 and 0.682 respectively) and lung cancer (P = 0.379 and 0.382 respectively), but a protection against SCCHN (P = 0.008 and 0.008 respectively), compared with the AA genotype or A allele. An additional meta-analysis including 19,423 cancer patients and 54,050 controls did not support such a risk association either. Our studies did not provide statistical evidence of an association between this rare TP53 variant and increased risk of melanoma, nor of lung cancer, but a possible protection against SCCHN.

dc.identifier.issn

1582-4934

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1582-4934

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https://hdl.handle.net/10161/18024

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eng

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Wiley

dc.relation.ispartof

Journal of cellular and molecular medicine

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10.1111/jcmm.12076

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Humans

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Melanoma

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Carcinoma, Squamous Cell

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Head and Neck Neoplasms

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Lung Neoplasms

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Genetic Predisposition to Disease

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Genotype

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Homozygote

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Polymorphism, Single Nucleotide

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Adolescent

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Adult

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Aged

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Aged, 80 and over

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Middle Aged

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European Continental Ancestry Group

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Female

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Male

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Tumor Suppressor Protein p53

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Young Adult

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Biomarkers, Tumor

dc.title

Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites.

dc.type

Journal article

duke.contributor.orcid

Wei, Qingyi|0000-0002-3845-9445|0000-0003-4115-4439

pubs.begin-page

873

pubs.end-page

878

pubs.issue

7

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School of Medicine

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Duke

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Duke Cancer Institute

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Institutes and Centers

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Population Health Sciences

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Basic Science Departments

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Medicine, Medical Oncology

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Medicine

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Clinical Science Departments

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Staff

pubs.publication-status

Published

pubs.volume

17

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