Comparison of long-term postoperative sequelae in patients with tetralogy of Fallot versus isolated pulmonic stenosis.

dc.contributor.author

Zdradzinski, Michael J

dc.contributor.author

Qureshi, Athar M

dc.contributor.author

Stewart, Robert

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Pettersson, Gosta

dc.contributor.author

Krasuski, Richard A

dc.coverage.spatial

United States

dc.date.accessioned

2015-12-03T15:36:09Z

dc.date.issued

2014-07-15

dc.description.abstract

Patients with tetralogy of Fallot (TOF) after complete repair and pulmonic stenosis (PS) after surgical valvotomy often develop significant pulmonic regurgitation (PR) that eventually requires valve replacement. Although criteria exist for the timing of pulmonary valve replacement in TOF, it remains less clear when to intervene in valvotomy patients and whether TOF recommendations can be applied. Our aim was to compare the structural and functional sequelae of valvotomy for PS with complete repair for TOF. We compared the clinical characteristics, electrocardiograms, echocardiograms, cardiac magnetic resonance imaging (MRI), and invasive hemodynamics of 109 adults (34 PS and 75 TOF) newly referred to a congenital heart disease center for evaluation of PR between 2005 and 2012. Both cohorts were similar in terms of baseline demographics and presenting New York Heart Association function class. Valvotomy patients had a slightly greater degree of PR by echocardiogram, although it was similar by cardiac MRI. Electrocardiography QRS width was greater in patients with TOF (114±27 vs 150±28 ms, p<0.001). MRI right ventricular ejection fraction (49±8 vs 41±11%, p=0.001) and left ventricular ejection fraction (59±7 vs 52±10%, p=0.002) were lower in patients with TOF. Pacemaker or defibrillator implantation was significantly greater in patients with TOF (3% vs 23%, p=0.011). In conclusion, patients postvalvotomy and complete repair present with similar degrees of PR and severity of symptoms. Biventricular systolic function and electrocardiography QRS width appear less affected, suggesting morphologic changes in TOF and its repair that extend beyond the effects of PR. These findings suggest the need for developing disease-specific guidelines for patients with PR postvalvotomy.

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/24878128

dc.identifier

S0002-9149(14)01055-8

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1879-1913

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https://hdl.handle.net/10161/10988

dc.language

eng

dc.publisher

Elsevier BV

dc.relation.ispartof

Am J Cardiol

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10.1016/j.amjcard.2014.04.041

dc.subject

Adult

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Cardiac Surgical Procedures

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Echocardiography

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Electrocardiography

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Female

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Follow-Up Studies

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Humans

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Male

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Middle Aged

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Postoperative Period

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Pulmonary Valve Stenosis

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Retrospective Studies

dc.subject

Stroke Volume

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Tetralogy of Fallot

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Time Factors

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Treatment Outcome

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Ventricular Function, Left

dc.title

Comparison of long-term postoperative sequelae in patients with tetralogy of Fallot versus isolated pulmonic stenosis.

dc.type

Journal article

duke.contributor.orcid

Krasuski, Richard A|0000-0003-3150-5215

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/24878128

pubs.begin-page

300

pubs.end-page

304

pubs.issue

2

pubs.organisational-group

Clinical Science Departments

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Duke

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Medicine

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Medicine, Cardiology

pubs.organisational-group

School of Medicine

pubs.publication-status

Published

pubs.volume

114

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