MEF2 and the Right Ventricle: From Development to Disease.

dc.contributor.author

Clapham, Katharine R

dc.contributor.author

Singh, Inderjit

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Capuano, Isabella S

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Rajagopal, Sudarshan

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Chun, Hyung J

dc.date.accessioned

2020-04-01T14:37:49Z

dc.date.available

2020-04-01T14:37:49Z

dc.date.issued

2019-01

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2020-04-01T14:37:48Z

dc.description.abstract

Pulmonary arterial hypertension is a progressive and ultimately life-limiting disease in which survival is closely linked to right ventricular function. The right ventricle remains relatively understudied, as it is known to have key developmental and structural differences from the left ventricle. Here, we will highlight what is known about the right ventricle in normal physiology and in the disease state of pulmonary arterial hypertension. Specifically, we will explore the role of the family of MEF2 (myocyte enhancer factor 2) transcription factors in right ventricular development, its response to increased afterload, and in the endothelial dysfunction that characterizes pulmonary arterial hypertension. Finally, we will turn to review potentially novel therapeutic strategies targeting these pathways.

dc.identifier.issn

2297-055X

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2297-055X

dc.identifier.uri

https://hdl.handle.net/10161/20334

dc.language

eng

dc.publisher

Frontiers Media SA

dc.relation.ispartof

Frontiers in cardiovascular medicine

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10.3389/fcvm.2019.00029

dc.subject

HDAC

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MEF2

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hypertrophy

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pulmonary hypertension

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right ventricle

dc.title

MEF2 and the Right Ventricle: From Development to Disease.

dc.type

Journal article

duke.contributor.orcid

Rajagopal, Sudarshan|0000-0002-3443-5040

pubs.begin-page

29

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School of Medicine

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Biochemistry

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Medicine, Cardiology

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Duke

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Basic Science Departments

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Medicine

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Clinical Science Departments

pubs.publication-status

Published

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6

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