Mucosal Associated Invariant T (MAIT) Cell Responses Differ by Sex in COVID-19.
dc.contributor.author | Yu, Chen | |
dc.contributor.author | Littleton, Sejiro | |
dc.contributor.author | Giroux, Nicholas S | |
dc.contributor.author | Mathew, Rose | |
dc.contributor.author | Ding, Shengli | |
dc.contributor.author | Kalnitsky, Joan | |
dc.contributor.author | Yang, Yuchen | |
dc.contributor.author | Petzold, Elizabeth | |
dc.contributor.author | Chung, Hong A | |
dc.contributor.author | Rivera, Grecia O | |
dc.contributor.author | Rotstein, Tomer | |
dc.contributor.author | Xi, Rui | |
dc.contributor.author | Ko, Emily R | |
dc.contributor.author | Tsalik, Ephraim L | |
dc.contributor.author | Sempowski, Gregory D | |
dc.contributor.author | Denny, Thomas N | |
dc.contributor.author | Burke, Thomas W | |
dc.contributor.author | McClain, Micah T | |
dc.contributor.author | Woods, Christopher W | |
dc.contributor.author | Shen, Xiling | |
dc.contributor.author | Saban, Daniel R | |
dc.date.accessioned | 2021-05-06T12:34:02Z | |
dc.date.available | 2021-05-06T12:34:02Z | |
dc.date.issued | 2021-04-13 | |
dc.date.updated | 2021-05-06T12:33:57Z | |
dc.description.abstract | Sexual dimorphisms in immune responses contribute to coronavirus disease 2019 (COVID-19) outcomes, yet the mechanisms governing this disparity remain incompletely understood. We carried out sex-balanced sampling of peripheral blood mononuclear cells from confirmed COVID-19 inpatients and outpatients, uninfected close contacts, and healthy controls for 36-color flow cytometry and single cell RNA-sequencing. Our results revealed a pronounced reduction of circulating mucosal associated invariant T (MAIT) cells in infected females. Integration of published COVID-19 airway tissue datasets implicate that this reduction represented a major wave of MAIT cell extravasation during early infection in females. Moreover, female MAIT cells possessed an immunologically active gene signature, whereas male counterparts were pro-apoptotic. Collectively, our findings uncover a female-specific protective MAIT profile, potentially shedding light on reduced COVID-19 susceptibility in females. | |
dc.identifier | S2666-6340(21)00157-4 | |
dc.identifier.issn | 2666-6359 | |
dc.identifier.issn | 2666-6340 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Elsevier BV | |
dc.relation.ispartof | Med (New York, N.Y.) | |
dc.relation.isversionof | 10.1016/j.medj.2021.04.008 | |
dc.subject | IL-7 | |
dc.subject | SARS-CoV-2 | |
dc.subject | apoptosis | |
dc.subject | innate immunity | |
dc.subject | monocyte | |
dc.title | Mucosal Associated Invariant T (MAIT) Cell Responses Differ by Sex in COVID-19. | |
dc.type | Journal article | |
duke.contributor.orcid | Giroux, Nicholas S|0000-0003-3801-4689 | |
duke.contributor.orcid | Tsalik, Ephraim L|0000-0002-6417-2042 | |
duke.contributor.orcid | Sempowski, Gregory D|0000-0003-0391-6594 | |
duke.contributor.orcid | Burke, Thomas W|0000-0003-0592-5822 | |
duke.contributor.orcid | Woods, Christopher W|0000-0001-7240-2453 | |
duke.contributor.orcid | Shen, Xiling|0000-0002-4978-3531 | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Duke Human Vaccine Institute | |
pubs.organisational-group | Duke Global Health Institute | |
pubs.organisational-group | Pathology | |
pubs.organisational-group | Medicine, Duke Human Vaccine Institute | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | University Institutes and Centers | |
pubs.organisational-group | Institutes and Provost's Academic Units | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Medicine | |
pubs.organisational-group | Pratt School of Engineering | |
pubs.organisational-group | Biomedical Engineering | |
pubs.organisational-group | Electrical and Computer Engineering | |
pubs.organisational-group | Duke Cancer Institute | |
pubs.organisational-group | Molecular Genetics and Microbiology | |
pubs.organisational-group | Pharmacology & Cancer Biology | |
pubs.organisational-group | Basic Science Departments | |
pubs.publication-status | Published |
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