Mucosal Associated Invariant T (MAIT) Cell Responses Differ by Sex in COVID-19.

dc.contributor.author

Yu, Chen

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Littleton, Sejiro

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Giroux, Nicholas S

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Mathew, Rose

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Ding, Shengli

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Kalnitsky, Joan

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Yang, Yuchen

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Petzold, Elizabeth

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Chung, Hong A

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Rivera, Grecia O

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Rotstein, Tomer

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Xi, Rui

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Ko, Emily R

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Tsalik, Ephraim L

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Sempowski, Gregory D

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Denny, Thomas N

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Burke, Thomas W

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McClain, Micah T

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Woods, Christopher W

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Shen, Xiling

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Saban, Daniel R

dc.date.accessioned

2021-05-06T12:34:02Z

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2021-05-06T12:34:02Z

dc.date.issued

2021-04-13

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2021-05-06T12:33:57Z

dc.description.abstract

Sexual dimorphisms in immune responses contribute to coronavirus disease 2019 (COVID-19) outcomes, yet the mechanisms governing this disparity remain incompletely understood. We carried out sex-balanced sampling of peripheral blood mononuclear cells from confirmed COVID-19 inpatients and outpatients, uninfected close contacts, and healthy controls for 36-color flow cytometry and single cell RNA-sequencing. Our results revealed a pronounced reduction of circulating mucosal associated invariant T (MAIT) cells in infected females. Integration of published COVID-19 airway tissue datasets implicate that this reduction represented a major wave of MAIT cell extravasation during early infection in females. Moreover, female MAIT cells possessed an immunologically active gene signature, whereas male counterparts were pro-apoptotic. Collectively, our findings uncover a female-specific protective MAIT profile, potentially shedding light on reduced COVID-19 susceptibility in females.

dc.identifier

S2666-6340(21)00157-4

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2666-6359

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2666-6340

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https://hdl.handle.net/10161/22841

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eng

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Elsevier BV

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Med (New York, N.Y.)

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10.1016/j.medj.2021.04.008

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IL-7

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SARS-CoV-2

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apoptosis

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innate immunity

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monocyte

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Mucosal Associated Invariant T (MAIT) Cell Responses Differ by Sex in COVID-19.

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Journal article

duke.contributor.orcid

Giroux, Nicholas S|0000-0003-3801-4689

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Tsalik, Ephraim L|0000-0002-6417-2042

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Sempowski, Gregory D|0000-0003-0391-6594

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Burke, Thomas W|0000-0003-0592-5822

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Woods, Christopher W|0000-0001-7240-2453

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Shen, Xiling|0000-0002-4978-3531

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School of Medicine

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Duke Human Vaccine Institute

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Duke Global Health Institute

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Pathology

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Medicine, Duke Human Vaccine Institute

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Duke

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Institutes and Centers

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University Institutes and Centers

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Institutes and Provost's Academic Units

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Clinical Science Departments

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Medicine

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Pratt School of Engineering

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Biomedical Engineering

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Electrical and Computer Engineering

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Duke Cancer Institute

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Molecular Genetics and Microbiology

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Pharmacology & Cancer Biology

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Basic Science Departments

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