Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection.
| dc.contributor.author | Naggie, Susanna | |
| dc.contributor.author | Swiderska-Syn, Marzena | |
| dc.contributor.author | Choi, Steve | |
| dc.contributor.author | Lusk, Sam | |
| dc.contributor.author | Lan, Audrey | |
| dc.contributor.author | Ferrari, Guido | |
| dc.contributor.author | Syn, Wing-Kin | |
| dc.contributor.author | Guy, Cynthia D | |
| dc.contributor.author | Diehl, Anna Mae | |
| dc.date.accessioned | 2023-03-02T15:12:18Z | |
| dc.date.available | 2023-03-02T15:12:18Z | |
| dc.date.issued | 2018-07 | |
| dc.date.updated | 2023-03-02T15:12:17Z | |
| dc.description.abstract | Liver disease is a leading cause of HIV-related mortality. Hepatitis C virus (HCV)-related fibrogenesis is accelerated in the setting of HIV coinfection, yet the mechanisms underlying this aggressive pathogenesis are unclear. We identified formalin-fixed paraffin-embedded liver tissue for HIV-infected patients, HCV-infected patients, HIV/HCV-coinfected patients, and controls at Duke University Medical Center. De-identified sections were stained for markers against the wound repair Hedgehog (Hh) pathway, resident T-lymphocytes, and immune activation and cellular aging. HIV infection was independently associated with Hh activation and markers of immune dysregulation in the liver tissue. | |
| dc.identifier | ofy138 | |
| dc.identifier.issn | 2328-8957 | |
| dc.identifier.issn | 2328-8957 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Oxford University Press (OUP) | |
| dc.relation.ispartof | Open forum infectious diseases | |
| dc.relation.isversionof | 10.1093/ofid/ofy138 | |
| dc.subject | GLI | |
| dc.subject | Hedgehog | |
| dc.subject | Sonic Hedgehog | |
| dc.subject | fibrogenesis | |
| dc.subject | hepatitis C virus | |
| dc.subject | human immunodeficiency virus | |
| dc.subject | patched | |
| dc.subject | pathogenesis | |
| dc.subject | wound repair | |
| dc.title | Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Naggie, Susanna|0000-0001-7721-6975 | |
| duke.contributor.orcid | Choi, Steve|0000-0001-9228-4060 | |
| duke.contributor.orcid | Ferrari, Guido|0000-0001-7747-3349 | |
| pubs.begin-page | ofy138 | |
| pubs.issue | 7 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Molecular Genetics and Microbiology | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Pathology | |
| pubs.organisational-group | Surgery | |
| pubs.organisational-group | Medicine, Gastroenterology | |
| pubs.organisational-group | Medicine, Infectious Diseases | |
| pubs.organisational-group | Surgery, Surgical Sciences | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.organisational-group | Duke Human Vaccine Institute | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.organisational-group | Duke Global Health Institute | |
| pubs.organisational-group | Regeneration Next Initiative | |
| pubs.publication-status | Published | |
| pubs.volume | 5 |
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