Colonizing the heart from the epicardial side.

Bursac, Nenad

England

2014-04-16T17:12:32Z

2012-04-30

The clinical use of stem cells, such as bone marrow-derived and, more recently, resident cardiac stem cells, offers great promise for treatment of myocardial infarction and heart failure. The epicardium-derived cells have also attracted attention for their angiogenic paracrine actions and ability to differentiate into cardiomyocytes and vascular cells when activated during cardiac injury. In a recent study, Chong and colleagues have described a distinct population of epicardium-derived mesenchymal stem cells that reside in a perivascular niche of the heart and have a broad multilineage potential. Exploring the therapeutic capacity of these cells will be an exciting future endeavor.

http://www.ncbi.nlm.nih.gov/pubmed/22546531

scrt106

1757-6512

https://hdl.handle.net/10161/8428

eng

Springer Science and Business Media LLC

Stem Cell Res Ther

10.1186/scrt106

Animals

Bone Marrow Cells

Mesenchymal Stromal Cells

Myocytes, Cardiac

Pericardium

Colonizing the heart from the epicardial side.

Journal article

http://www.ncbi.nlm.nih.gov/pubmed/22546531

15

2

Biomedical Engineering

Clinical Science Departments

Duke

Duke Cancer Institute

Institutes and Centers

Medicine

Medicine, Cardiology

Pratt School of Engineering

School of Medicine

Published online

3