Adult age differences in functional connectivity during executive control.

dc.contributor.author

Madden, David J

dc.contributor.author

Costello, Matthew C

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Dennis, Nancy A

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Davis, Simon W

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Shepler, Anne M

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Spaniol, Julia

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Bucur, Barbara

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Cabeza, Roberto

dc.coverage.spatial

United States

dc.date.accessioned

2017-01-11T23:14:07Z

dc.date.issued

2010-08-15

dc.description.abstract

Task switching requires executive control processes that undergo age-related decline. Previous neuroimaging studies have identified age-related differences in brain activation associated with global switching effects (dual-task blocks versus single-task blocks), but age-related differences in activation during local switching effects (switch trials versus repeat trials, within blocks) have not been investigated. This experiment used functional magnetic resonance imaging (fMRI), and diffusion tensor imaging (DTI), to examine adult age differences in task switching across adjacent trials (i.e., local task switching). During fMRI scanning, participants performed a cued, word categorization task. From interspersed cue-only trials, switch-related processing associated with the cue was estimated separately from the target. Activation associated with task switching, within a distributed frontoparietal network, differed for cue- and target-related processing. The magnitude of event-related activation for task switching was similar for younger adults (n=20; 18-27years) and older adults (n=20; 60-85years), although activation sustained throughout the on-tasks periods exhibited some age-related decline. Critically, the functional connectivity of switch-related regions, during cue processing, was higher for younger adults than for older adults, whereas functional connectivity during target processing was comparable across the age groups. Further, individual differences in cue-related functional connectivity shared a substantial portion of the age-related variability in the efficiency of target categorization response (drift rate). This age-related difference in functional connectivity, however, was independent of white matter integrity within task-relevant regions. These findings highlight the functional connectivity of frontoparietal activation as a potential source of age-related decline in executive control.

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/20434565

dc.identifier

S1053-8119(10)00661-0

dc.identifier.eissn

1095-9572

dc.identifier.uri

https://hdl.handle.net/10161/13477

dc.language

eng

dc.publisher

Elsevier BV

dc.relation.ispartof

Neuroimage

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10.1016/j.neuroimage.2010.04.249

dc.subject

Adolescent

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Adult

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Aged

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Aged, 80 and over

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Aging

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Brain

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Brain Mapping

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Cognition

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Cues

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Diffusion Tensor Imaging

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Executive Function

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Female

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Humans

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Language Tests

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Magnetic Resonance Imaging

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Male

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Middle Aged

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Neural Pathways

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Neuropsychological Tests

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Reaction Time

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Young Adult

dc.title

Adult age differences in functional connectivity during executive control.

dc.type

Journal article

duke.contributor.orcid

Madden, David J|0000-0003-2815-6552

duke.contributor.orcid

Davis, Simon W|0000-0002-5943-0756

duke.contributor.orcid

Cabeza, Roberto|0000-0001-7999-1182

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/20434565

pubs.begin-page

643

pubs.end-page

657

pubs.issue

2

pubs.organisational-group

Center for Cognitive Neuroscience

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Center for Population Health & Aging

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Clinical Science Departments

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Duke

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Duke Institute for Brain Sciences

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Duke Population Research Institute

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Duke Science & Society

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Duke-UNC Center for Brain Imaging and Analysis

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Initiatives

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Institutes and Centers

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Institutes and Provost's Academic Units

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Neurology

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Neurology, Behavioral Neurology

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Psychiatry & Behavioral Sciences

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Psychiatry & Behavioral Sciences, Geriatric Behavioral Health

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Psychology and Neuroscience

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Sanford School of Public Policy

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School of Medicine

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Trinity College of Arts & Sciences

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University Institutes and Centers

pubs.publication-status

Published

pubs.volume

52

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