Strategies for Temporal and Spectral Imaging with X-ray Computed Tomography

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Date

2012

Authors

Johnston, Samuel Morris

Advisors

Badea, Cristian T

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Abstract

X-ray micro-CT is widely used for small animal imaging in preclinical studies of cardiopulmonary disease, but further development is needed to improve spatial resolution, temporal resolution, and material contrast. This study presents a set of tools that achieve these improvements. These tools include the mathematical formulation and computational implementation of algorithms for calibration, image reconstruction, and image analysis with our custom micro-CT system. These tools are tested in simulations and in experiments with live animals. With these tools, it is possible to visualize the distribution of a contrast agent throughout the body of a mouse as it changes over time, and produce 5-dimensional images (3 spatial dimensions + time + energy) of the cardiac cycle.

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Citation

Johnston, Samuel Morris (2012). Strategies for Temporal and Spectral Imaging with X-ray Computed Tomography. Dissertation, Duke University. Retrieved from https://hdl.handle.net/10161/5589.

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