dc.contributor.advisor	Badea, Cristian T
dc.contributor.author	Johnston, Samuel Morris
dc.date.accessioned	2012-05-25T20:21:05Z
dc.date.available	2013-05-20T04:30:06Z
dc.date.issued	2012
dc.department	Biomedical Engineering
dc.description.abstract	X-ray micro-CT is widely used for small animal imaging in preclinical studies of cardiopulmonary disease, but further development is needed to improve spatial resolution, temporal resolution, and material contrast. This study presents a set of tools that achieve these improvements. These tools include the mathematical formulation and computational implementation of algorithms for calibration, image reconstruction, and image analysis with our custom micro-CT system. These tools are tested in simulations and in experiments with live animals. With these tools, it is possible to visualize the distribution of a contrast agent throughout the body of a mouse as it changes over time, and produce 5-dimensional images (3 spatial dimensions + time + energy) of the cardiac cycle.
dc.identifier.uri	https://hdl.handle.net/10161/5589
dc.subject	Medical imaging and radiology
dc.subject	Biomedical engineering
dc.subject	Computer science
dc.subject	Calibration
dc.subject	Reconstruction
dc.subject	small animal
dc.subject	Spectral
dc.subject	Temporal
dc.subject	X-ray CT
dc.title	Strategies for Temporal and Spectral Imaging with X-ray Computed Tomography
dc.type	Dissertation
duke.embargo.months	12

Strategies for Temporal and Spectral Imaging with X-ray Computed Tomography

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