Pulmonary toxicity after intraperitoneal mitomycin C: A case report of a rare complication of HIPEC

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2017-02-20

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Abstract

© 2016 The Author(s). Background: Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has become a common treatment approach for disseminated appendiceal neoplasms. Systemic absorption of intraperitoneal chemotherapeutics may lead to drug-induced toxicity, most commonly neutropenia. Mitomycin C has been the most commonly used chemotherapeutic in HIPEC for the past several decades. Case presentation: Here, we describe a rare pulmonary complication secondary to intraperitoneal administration of mitomycin C. Conclusions: While rare, intraperitoneal mitomycin C has the potential to cause serious pulmonary toxicity that should be considered with administration. To our knowledge, this report represents only the second case described in the literature.

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10.1186/s12957-016-1047-6

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Abel, Melissa L, George Kokosis and Dan G Blazer (2017). Pulmonary toxicity after intraperitoneal mitomycin C: A case report of a rare complication of HIPEC. World Journal of Surgical Oncology, 15(1). 10.1186/s12957-016-1047-6 Retrieved from https://hdl.handle.net/10161/15384.

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Blazer

Dan German Blazer

Professor of Surgery

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