Early onset severe ATP1A2 epileptic encephalopathy: Clinical characteristics and underlying mutations.
| dc.contributor.author | Moya-Mendez, Mary E | |
| dc.contributor.author | Mueller, David M | |
| dc.contributor.author | Pratt, Milton | |
| dc.contributor.author | Bonner, Melanie | |
| dc.contributor.author | Elliott, Courtney | |
| dc.contributor.author | Hunanyan, Arsen | |
| dc.contributor.author | Kucera, Gary | |
| dc.contributor.author | Bock, Cheryl | |
| dc.contributor.author | Prange, Lyndsey | |
| dc.contributor.author | Jasien, Joan | |
| dc.contributor.author | Keough, Karen | |
| dc.contributor.author | Shashi, Vandana | |
| dc.contributor.author | McDonald, Marie | |
| dc.contributor.author | Mikati, Mohamad A | |
| dc.date.accessioned | 2021-02-19T17:02:37Z | |
| dc.date.available | 2021-02-19T17:02:37Z | |
| dc.date.issued | 2021-01-22 | |
| dc.date.updated | 2021-02-19T17:02:36Z | |
| dc.description.abstract | BackgroundATP1A2 mutations cause hemiplegic migraine with or without epilepsy or acute reversible encephalopathy. Typical onset is in adulthood or older childhood without subsequent severe long-term developmental impairments.AimWe aimed to describe the manifestations of early onset severe ATP1A2-related epileptic encephalopathy and its underlying mutations in a cohort of seven patients.MethodsA retrospective chart review of a cohort of seven patients was conducted. Response to open-label memantine therapy, used off-label due to its NMDA receptor antagonist effects, was assessed by the Global Rating Scale of Change (GRSC) and Clinical Global Impression Scale of Improvement (CGI-I) methodologies. Molecular modeling was performed using PyMol program.ResultsPatients (age 2.5-20 years) had symptom onset at an early age (6 days-1 year). Seizures were either focal or generalized. Common features were: drug resistance, recurrent status epilepticus, etc., severe developmental delay with episodes of acute severe encephalopathy often with headaches, dystonias, hemiplegias, seizures, and developmental regression. All had variants predicted to be disease causing (p.Ile293Met, p.Glu1000Lys, c.1017+5G>A, p.Leu809Arg, and 3 patients with p.Met813Lys). Modeling revealed that mutations interfered with ATP1A2 ion binding and translocation sites. Memantine, given to five, was tolerated in all (mean treatment: 2.3 years, range 6 weeks-4.8 years) with some improvements reported in all five.ConclusionsOur observations describe a distinctive clinical profile of seven unrelated probands with early onset severe ATP1A2-related epileptic encephalopathy, provide insights into structure-function relationships of ATP1A2 mutations, and support further studies of NMDAR antagonist therapy in ATP1A2-encephalopathy. | |
| dc.identifier | S1525-5050(20)30912-4 | |
| dc.identifier.issn | 1525-5050 | |
| dc.identifier.issn | 1525-5069 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Elsevier BV | |
| dc.relation.ispartof | Epilepsy & behavior : E&B | |
| dc.relation.isversionof | 10.1016/j.yebeh.2020.107732 | |
| dc.subject | ATP1A2 | |
| dc.subject | Alternating Hemiplegia of Childhood | |
| dc.subject | Encephalopathy | |
| dc.subject | Familial Hemiplegic Migraine | |
| dc.subject | Memantine | |
| dc.subject | NMDA Receptor Antagonist | |
| dc.title | Early onset severe ATP1A2 epileptic encephalopathy: Clinical characteristics and underlying mutations. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Mikati, Mohamad A|0000-0003-0363-8715 | |
| pubs.begin-page | 107732 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Duke-UNC Center for Brain Imaging and Analysis | |
| pubs.organisational-group | Neurobiology | |
| pubs.organisational-group | Duke Science & Society | |
| pubs.organisational-group | Duke Institute for Brain Sciences | |
| pubs.organisational-group | Pediatrics, Neurology | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Initiatives | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.organisational-group | Pediatrics | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Pediatrics, Medical Genetics | |
| pubs.publication-status | Published | |
| pubs.volume | 116 |
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