A novel recombinant immunotoxin-based therapy targeting wild-type and mutant EGFR improves survival in murine models of glioblastoma.
| dc.contributor.author | Chandramohan, Vidyalakshmi | |
| dc.contributor.author | Bigner, Darell D | |
| dc.date.accessioned | 2022-09-01T13:32:24Z | |
| dc.date.available | 2022-09-01T13:32:24Z | |
| dc.date.issued | 2013-12 | |
| dc.date.updated | 2022-09-01T13:32:24Z | |
| dc.description.abstract | Both the amplification of the gene coding for wild-type (wt) epidermal growth factor receptor (EGFR) and the overexpression of the EGFR deletion mutant, commonly known as EGFRvIII, are hallmarks of glioblastoma. We have recently reported a novel, recombinant immunotoxin, D2C7-(scdsFv)-PE38KDEL, that targets both wt EGFR and EGFRvIII, exhibiting potent antineoplastic effects against established murine gliomas. | |
| dc.identifier | 2013ONCOIMM0299 | |
| dc.identifier.issn | 2162-4011 | |
| dc.identifier.issn | 2162-402X | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Informa UK Limited | |
| dc.relation.ispartof | Oncoimmunology | |
| dc.relation.isversionof | 10.4161/onci.26852 | |
| dc.subject | Pseudomonasexotoxin | |
| dc.subject | bispecific antibody | |
| dc.subject | brain tumors | |
| dc.subject | convection-enhanced delivery | |
| dc.subject | glioma-associated antigens | |
| dc.title | A novel recombinant immunotoxin-based therapy targeting wild-type and mutant EGFR improves survival in murine models of glioblastoma. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Chandramohan, Vidyalakshmi|0000-0002-0653-3014 | |
| duke.contributor.orcid | Bigner, Darell D|0000-0001-5548-4899 | |
| pubs.begin-page | e26852 | |
| pubs.issue | 12 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Pathology | |
| pubs.organisational-group | Surgery | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Neurosurgery | |
| pubs.organisational-group | Neurosurgery, Neuro-Oncology | |
| pubs.publication-status | Published | |
| pubs.volume | 2 |
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