Noninvasive monitoring of tissue hemoglobin using UV-VIS diffuse reflectance spectroscopy: a pilot study.
| dc.contributor.author | Bender, Janelle E | |
| dc.contributor.author | Shang, Allan B | |
| dc.contributor.author | Moretti, Eugene W | |
| dc.contributor.author | Yu, Bing | |
| dc.contributor.author | Richards, Lisa M | |
| dc.contributor.author | Ramanujam, Nirmala | |
| dc.coverage.spatial | United States | |
| dc.date.accessioned | 2011-06-21T17:27:43Z | |
| dc.date.issued | 2009-12-21 | |
| dc.description.abstract | We conducted a pilot study on 10 patients undergoing general surgery to test the feasibility of diffuse reflectance spectroscopy in the visible wavelength range as a noninvasive monitoring tool for blood loss during surgery. Ratios of raw diffuse reflectance at wavelength pairs were tested as a first-pass for estimating hemoglobin concentration. Ratios can be calculated easily and rapidly with limited post-processing, and so this can be considered a near real-time monitoring device. We found the best hemoglobin correlations were when ratios at isosbestic points of oxy- and deoxyhemoglobin were used, specifically 529/500 nm. Baseline subtraction improved correlations, specifically at 520/509 nm. These results demonstrate proof-of-concept for the ability of this noninvasive device to monitor hemoglobin concentration changes due to surgical blood loss. The 529/500 nm ratio also appears to account for variations in probe pressure, as determined from measurements on two volunteers. | |
| dc.description.version | Version of Record | |
| dc.identifier | ||
| dc.identifier | 192701 | |
| dc.identifier.eissn | 1094-4087 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.language.iso | en_US | |
| dc.publisher | The Optical Society | |
| dc.relation.ispartof | Opt Express | |
| dc.relation.journal | Optics Express | |
| dc.subject | Biomarkers | |
| dc.subject | Blood Chemical Analysis | |
| dc.subject | Blood Loss, Surgical | |
| dc.subject | Diagnosis, Computer-Assisted | |
| dc.subject | Feasibility Studies | |
| dc.subject | Hemoglobins | |
| dc.subject | Humans | |
| dc.subject | Oxygen | |
| dc.subject | Pilot Projects | |
| dc.subject | Postoperative Hemorrhage | |
| dc.subject | Reproducibility of Results | |
| dc.subject | Sensitivity and Specificity | |
| dc.subject | Spectrophotometry, Ultraviolet | |
| dc.title | Noninvasive monitoring of tissue hemoglobin using UV-VIS diffuse reflectance spectroscopy: a pilot study. | |
| dc.title.alternative | ||
| dc.type | Journal article | |
| duke.date.pubdate | 2009-12-21 | |
| duke.description.issue | 26 | |
| duke.description.volume | 17 | |
| pubs.author-url | ||
| pubs.begin-page | 23396 | |
| pubs.end-page | 23409 | |
| pubs.issue | 26 | |
| pubs.organisational-group | Anesthesiology | |
| pubs.organisational-group | Anesthesiology, General, Vascular, High Risk Transplant & Critical Care | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Biomedical Engineering | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Duke Science & Society | |
| pubs.organisational-group | Initiatives | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | Nursing | |
| pubs.organisational-group | Pharmacology & Cancer Biology | |
| pubs.organisational-group | Pratt School of Engineering | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | School of Nursing | |
| pubs.publication-status | Published | |
| pubs.volume | 17 |