Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.
dc.contributor.author | Stafford-Smith, Mark | |
dc.contributor.author | Li, Yi-Ju | |
dc.contributor.author | Mathew, Joseph P | |
dc.contributor.author | Li, Yen-Wei | |
dc.contributor.author | Ji, Yunqi | |
dc.contributor.author | Phillips-Bute, Barbara G | |
dc.contributor.author | Milano, Carmelo A | |
dc.contributor.author | Newman, Mark F | |
dc.contributor.author | Kraus, William E | |
dc.contributor.author | Kertai, Miklos D | |
dc.contributor.author | Shah, Svati H | |
dc.contributor.author | Podgoreanu, Mihai V | |
dc.contributor.author | Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2017-03-01T14:57:06Z | |
dc.date.available | 2017-03-01T14:57:06Z | |
dc.date.issued | 2015-10 | |
dc.description.abstract | Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since prior studies have supported a genetic basis for postoperative AKI, we conducted a genome-wide association study (GWAS) for AKI following coronary bypass graft (CABG) surgery. The discovery data set consisted of 873 nonemergent CABG surgery patients with cardiopulmonary bypass (PEGASUS), while a replication data set had 380 cardiac surgical patients (CATHGEN). Single-nucleotide polymorphism (SNP) data were based on Illumina Human610-Quad (PEGASUS) and OMNI1-Quad (CATHGEN) BeadChips. We used linear regression with adjustment for a clinical AKI risk score to test SNP associations with the postoperative peak rise relative to preoperative serum creatinine concentration as a quantitative AKI trait. Nine SNPs meeting significance in the discovery set were detected. The rs13317787 in GRM7|LMCD1-AS1 intergenic region (3p21.6) and rs10262995 in BBS9 (7p14.3) were replicated with significance in the CATHGEN data set and exhibited significantly strong overall association following meta-analysis. Additional fine mapping using imputed SNPs across these two regions and meta-analysis found genome-wide significance at the GRM7|LMCD1-AS1 locus and a significantly strong association at BBS9. Thus, through an unbiased GWAS approach, we found two new loci associated with post-CABG AKI providing new insights into the pathogenesis of perioperative AKI. | |
dc.identifier | ||
dc.identifier | S2157-1716(15)32247-4 | |
dc.identifier.eissn | 1523-1755 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Elsevier BV | |
dc.relation.ispartof | Kidney Int | |
dc.relation.isversionof | 10.1038/ki.2015.161 | |
dc.subject | Acute Kidney Injury | |
dc.subject | Aged | |
dc.subject | Biomarkers | |
dc.subject | Coronary Artery Bypass | |
dc.subject | Creatinine | |
dc.subject | Databases, Genetic | |
dc.subject | Female | |
dc.subject | Genetic Loci | |
dc.subject | Genetic Markers | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Humans | |
dc.subject | Linear Models | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Phenotype | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Risk Assessment | |
dc.subject | Risk Factors | |
dc.subject | Time Factors | |
dc.title | Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci. | |
dc.type | Journal article | |
duke.contributor.orcid | Li, Yi-Ju|0000-0001-6996-4834 | |
duke.contributor.orcid | Mathew, Joseph P|0000-0002-3815-4131 | |
duke.contributor.orcid | Kraus, William E|0000-0003-1930-9684 | |
duke.contributor.orcid | Shah, Svati H|0000-0002-3495-2830 | |
pubs.author-url | ||
pubs.begin-page | 823 | |
pubs.end-page | 832 | |
pubs.issue | 4 | |
pubs.organisational-group | Anesthesiology | |
pubs.organisational-group | Anesthesiology, Cardiothoracic | |
pubs.organisational-group | Basic Science Departments | |
pubs.organisational-group | Biomedical Engineering | |
pubs.organisational-group | Biostatistics & Bioinformatics | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Duke Cancer Institute | |
pubs.organisational-group | Duke Clinical Research Institute | |
pubs.organisational-group | Duke Molecular Physiology Institute | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Medicine | |
pubs.organisational-group | Medicine, Cardiology | |
pubs.organisational-group | Pathology | |
pubs.organisational-group | Pediatrics | |
pubs.organisational-group | Pratt School of Engineering | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | School of Nursing | |
pubs.organisational-group | School of Nursing - Secondary Group | |
pubs.organisational-group | Surgery | |
pubs.organisational-group | Surgery, Cardiovascular and Thoracic Surgery | |
pubs.publication-status | Published | |
pubs.volume | 88 |
Files
Original bundle
- Name:
- Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.pdf
- Size:
- 696.24 KB
- Format:
- Adobe Portable Document Format