Vitamin D levels and cognition in elderly adults in China.
| dc.contributor.author | Chei, Choy-Lye | |
| dc.contributor.author | Raman, Prassanna | |
| dc.contributor.author | Yin, Zhao-Xue | |
| dc.contributor.author | Shi, Xiao-Ming | |
| dc.contributor.author | Zeng, Yi | |
| dc.contributor.author | Matchar, David B | |
| dc.date.accessioned | 2021-05-11T07:37:59Z | |
| dc.date.available | 2021-05-11T07:37:59Z | |
| dc.date.issued | 2014-11 | |
| dc.date.updated | 2021-05-11T07:37:58Z | |
| dc.description.abstract | ObjectivesTo evaluate the association between vitamin D level and cognitive impairment in individuals aged 60 and older.DesignCross-sectional cohort study.SettingChinese Longitudinal Healthy Longevity Survey, a community-based cohort study in areas in China where the density of centenarians is exceptionally high.ParticipantsIndividuals with mean age of 84.9 ± 12.7 (N = 2,004).MeasurementsParticipants' cognitive state was evaluated using the Mini-Mental State Examination (MMSE). Vitamin D was measured in plasma using an enzyme-linked immunoassay.ResultsThe cross-sectional association between quartiles of plasma vitamin D level and cognitive impairment (MMSE score <18) was modeled using logistic regressions. Plasma vitamin D levels were lower in individuals with cognitive impairment (31.9 ± 15.3 nmol/L) than in those without (45.6 ± 19.6 nmol/L). There was a reverse association between plasma vitamin D and cognitive impairment. After adjusting for age, sex, chronic conditions, smoking and drinking habits, outdoor activities, depression, and activity of daily living limitations, the association remained significant. The multivariable-adjusted odds ratio for lowest versus highest vitamin D levels was 2.15 (95% confidence interval (CI) = 1.05-4.41) for cognitive impairment, and the multivariable odds ratio associated with a 1-standard deviation decrement in plasma vitamin D was 1.32 (95% CI = 1.00-1.74) for cognitive impairment.ConclusionLow plasma vitamin D levels were associated with greater odds of cognitive impairment. Further prospective studies in Asian populations are needed to examine the causal direction of this association. | |
| dc.identifier.issn | 0002-8614 | |
| dc.identifier.issn | 1532-5415 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Wiley | |
| dc.relation.ispartof | Journal of the American Geriatrics Society | |
| dc.relation.isversionof | 10.1111/jgs.13082 | |
| dc.subject | Humans | |
| dc.subject | Alzheimer Disease | |
| dc.subject | Vitamin D Deficiency | |
| dc.subject | Calcifediol | |
| dc.subject | Multivariate Analysis | |
| dc.subject | Odds Ratio | |
| dc.subject | Cross-Sectional Studies | |
| dc.subject | Mental Status Schedule | |
| dc.subject | Longevity | |
| dc.subject | Cross-Cultural Comparison | |
| dc.subject | Aged | |
| dc.subject | Aged, 80 and over | |
| dc.subject | Middle Aged | |
| dc.subject | China | |
| dc.subject | Female | |
| dc.subject | Male | |
| dc.subject | Statistics as Topic | |
| dc.title | Vitamin D levels and cognition in elderly adults in China. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Matchar, David B|0000-0003-3020-2108 | |
| pubs.begin-page | 2125 | |
| pubs.end-page | 2129 | |
| pubs.issue | 11 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.organisational-group | Duke Global Health Institute | |
| pubs.organisational-group | Pathology | |
| pubs.organisational-group | Medicine, General Internal Medicine | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Duke Population Research Institute | |
| pubs.organisational-group | Center for Population Health & Aging | |
| pubs.organisational-group | Duke Population Research Center | |
| pubs.organisational-group | Center for the Study of Aging and Human Development | |
| pubs.organisational-group | Medicine, Geriatrics | |
| pubs.organisational-group | Sanford School of Public Policy | |
| pubs.publication-status | Published | |
| pubs.volume | 62 |
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