Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations.
| dc.contributor.author | Wang, Mengyun | |
| dc.contributor.author | Li, Qiaoxin | |
| dc.contributor.author | Gu, Chengyuan | |
| dc.contributor.author | Zhu, Yao | |
| dc.contributor.author | Yang, Yajun | |
| dc.contributor.author | Wang, Jiucun | |
| dc.contributor.author | Jin, Li | |
| dc.contributor.author | He, Jing | |
| dc.contributor.author | Ye, Dingwei | |
| dc.contributor.author | Wei, Qingyi | |
| dc.date.accessioned | 2019-02-01T14:45:34Z | |
| dc.date.available | 2019-02-01T14:45:34Z | |
| dc.date.issued | 2017-04 | |
| dc.date.updated | 2019-02-01T14:45:32Z | |
| dc.description.abstract | Genetic variants of nucleotide excision repair (NER) genes have been extensively investigated for their roles in the development of prostate cancer (PCa); however, the published results have been inconsistent. In a hospital-based case-control study of 1,004 PCa cases and 1,055 cancer-free controls, we genotyped eight potentially functional single nucleotide polymorphisms (SNPs) of NER genes (i.e., XPC, rs2228001 T>G and rs1870134 G>C; XPD, rs13181 T>G and rs238406 G>T; XPG, rs1047768 T>C, rs751402 C>T, and rs17655 G>C; and XPF, rs2276464 G>C) and assessed their associations with risk of PCa by using logistic regression analysis. Among these eight SNPs investigated, only XPC rs1870134 CG/CC variant genotypes were associated with a decreased risk of prostate cancer under a dominant genetic model (adjusted odds ratio [OR] = 0.77, 95% confidence interval [CI] = 0.64-1.91, P = 0.003). Phenotype-genotype analysis also suggested that the XPC rs1870134 CG/CC variant genotypes were associated with significantly decreased expression levels of XPC mRNA in a mix population of different ethnicities. These findings suggested that XPC SNPs may contribute to risk of PCa in Eastern Chinese men. | |
| dc.identifier | 13848 | |
| dc.identifier.issn | 1949-2553 | |
| dc.identifier.issn | 1949-2553 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Impact Journals, LLC | |
| dc.relation.ispartof | Oncotarget | |
| dc.relation.isversionof | 10.18632/oncotarget.13848 | |
| dc.subject | Humans | |
| dc.subject | Prostatic Neoplasms | |
| dc.subject | Genetic Predisposition to Disease | |
| dc.subject | RNA, Messenger | |
| dc.subject | Risk Factors | |
| dc.subject | Case-Control Studies | |
| dc.subject | DNA Repair | |
| dc.subject | Polymorphism, Single Nucleotide | |
| dc.subject | Aged | |
| dc.subject | Middle Aged | |
| dc.subject | Asian Continental Ancestry Group | |
| dc.subject | Female | |
| dc.subject | Male | |
| dc.title | Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Wei, Qingyi|0000-0002-3845-9445|0000-0003-4115-4439 | |
| pubs.begin-page | 24362 | |
| pubs.end-page | 24371 | |
| pubs.issue | 15 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Population Health Sciences | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Medicine, Medical Oncology | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.publication-status | Published | |
| pubs.volume | 8 |
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