Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium.

dc.contributor.author

Dennis, Emily L

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Disner, Seth G

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Fani, Negar

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Salminen, Lauren E

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Logue, Mark

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Clarke, Emily K

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Haswell, Courtney C

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Averill, Christopher L

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Baugh, Lee A

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Bomyea, Jessica

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Bruce, Steven E

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Cha, Jiook

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Choi, Kyle

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Davenport, Nicholas D

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Densmore, Maria

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du Plessis, Stefan

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Forster, Gina L

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Frijling, Jessie L

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Gonenc, Atilla

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Gruber, Staci

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Grupe, Daniel W

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Guenette, Jeffrey P

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Hayes, Jasmeet

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Hofmann, David

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Ipser, Jonathan

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Jovanovic, Tanja

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Kelly, Sinead

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Kennis, Mitzy

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Kinzel, Philipp

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Koch, Saskia BJ

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Koerte, Inga

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Koopowitz, Sheri

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Korgaonkar, Mayuresh

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Krystal, John

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Lebois, Lauren AM

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Li, Gen

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Magnotta, Vincent A

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Manthey, Antje

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May, Geoff J

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Menefee, Deleene S

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Nawijn, Laura

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Nelson, Steven M

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Neufeld, Richard WJ

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Nitschke, Jack B

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O'Doherty, Daniel

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Peverill, Matthew

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Ressler, Kerry J

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Roos, Annerine

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Sheridan, Margaret A

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Sierk, Anika

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Simmons, Alan

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Simons, Raluca M

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Simons, Jeffrey S

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Stevens, Jennifer

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Suarez-Jimenez, Benjamin

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Sullivan, Danielle R

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Théberge, Jean

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Tran, Jana K

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van den Heuvel, Leigh

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van der Werff, Steven JA

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van Rooij, Sanne JH

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van Zuiden, Mirjam

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Velez, Carmen

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Verfaellie, Mieke

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Vermeiren, Robert RJM

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Wade, Benjamin SC

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Wager, Tor

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Walter, Henrik

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Winternitz, Sherry

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Wolff, Jonathan

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York, Gerald

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Zhu, Ye

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Zhu, Xi

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Abdallah, Chadi G

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Bryant, Richard

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Daniels, Judith K

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Davidson, Richard J

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Fercho, Kelene A

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Franz, Carol

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Geuze, Elbert

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Gordon, Evan M

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Kaufman, Milissa L

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Kremen, William S

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Lagopoulos, Jim

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Lanius, Ruth A

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Lyons, Michael J

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McCauley, Stephen R

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McGlinchey, Regina

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McLaughlin, Katie A

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Milberg, William

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Neria, Yuval

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Olff, Miranda

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Seedat, Soraya

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Shenton, Martha

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Sponheim, Scott R

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Stein, Dan J

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Stein, Murray B

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Straube, Thomas

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Tate, David F

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van der Wee, Nic JA

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Veltman, Dick J

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Wang, Li

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Wilde, Elisabeth A

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Thompson, Paul M

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Kochunov, Peter

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Jahanshad, Neda

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Morey, Rajendra A

dc.date.accessioned

2023-11-01T17:49:04Z

dc.date.available

2023-11-01T17:49:04Z

dc.date.issued

2021-08

dc.date.updated

2023-11-01T17:49:02Z

dc.description.abstract

A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed which may be partially due to relatively small sample sizes among studies. Altered structural connectivity may be both a neurobiological vulnerability for, and a result of, PTSD. In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3047 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium). Comparing regional white matter metrics across the full brain in 1426 individuals with PTSD and 1621 controls (2174 males/873 females) between ages 18-83, 92% of whom were trauma-exposed, we report associations between PTSD and disrupted white matter organization measured by lower fractional anisotropy (FA) in the tapetum region of the corpus callosum (Cohen's d = -0.11, p = 0.0055). The tapetum connects the left and right hippocampus, for which structure and function have been consistently implicated in PTSD. Results were consistent even after accounting for the effects of multiple potentially confounding variables: childhood trauma exposure, comorbid depression, history of traumatic brain injury, current alcohol abuse or dependence, and current use of psychotropic medications. Our results show that PTSD may be associated with alterations in the broader hippocampal network.

dc.identifier

10.1038/s41380-019-0631-x

dc.identifier.issn

1359-4184

dc.identifier.issn

1476-5578

dc.identifier.uri

https://hdl.handle.net/10161/29325

dc.language

eng

dc.publisher

Springer Science and Business Media LLC

dc.relation.ispartof

Molecular psychiatry

dc.relation.isversionof

10.1038/s41380-019-0631-x

dc.subject

Brain

dc.subject

Humans

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Stress Disorders, Post-Traumatic

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Anisotropy

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Adolescent

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Adult

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Aged

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Aged, 80 and over

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Middle Aged

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Female

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Male

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Young Adult

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Diffusion Tensor Imaging

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White Matter

dc.title

Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium.

dc.type

Journal article

pubs.begin-page

4315

pubs.end-page

4330

pubs.issue

8

pubs.organisational-group

Duke

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School of Medicine

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Clinical Science Departments

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Institutes and Centers

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Psychiatry & Behavioral Sciences

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Institutes and Provost's Academic Units

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University Institutes and Centers

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Duke Institute for Brain Sciences

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Psychiatry, Child & Family Mental Health & Community Psychiatry

pubs.organisational-group

Duke-UNC Center for Brain Imaging and Analysis

pubs.publication-status

Published

pubs.volume

26

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