Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium.

Dennis, Emily L

Disner, Seth G

Fani, Negar

Salminen, Lauren E

Logue, Mark

Clarke, Emily K

Haswell, Courtney C

Averill, Christopher L

Baugh, Lee A

Bomyea, Jessica

Bruce, Steven E

Cha, Jiook

Choi, Kyle

Davenport, Nicholas D

Densmore, Maria

du Plessis, Stefan

Forster, Gina L

Frijling, Jessie L

Gonenc, Atilla

Gruber, Staci

Grupe, Daniel W

Guenette, Jeffrey P

Hayes, Jasmeet

Hofmann, David

Ipser, Jonathan

Jovanovic, Tanja

Kelly, Sinead

Kennis, Mitzy

Kinzel, Philipp

Koch, Saskia BJ

Koerte, Inga

Koopowitz, Sheri

Korgaonkar, Mayuresh

Krystal, John

Lebois, Lauren AM

Li, Gen

Magnotta, Vincent A

Manthey, Antje

May, Geoff J

Menefee, Deleene S

Nawijn, Laura

Nelson, Steven M

Neufeld, Richard WJ

Nitschke, Jack B

O'Doherty, Daniel

Peverill, Matthew

Ressler, Kerry J

Roos, Annerine

Sheridan, Margaret A

Sierk, Anika

Simmons, Alan

Simons, Raluca M

Simons, Jeffrey S

Stevens, Jennifer

Suarez-Jimenez, Benjamin

Sullivan, Danielle R

Théberge, Jean

Tran, Jana K

van den Heuvel, Leigh

van der Werff, Steven JA

van Rooij, Sanne JH

van Zuiden, Mirjam

Velez, Carmen

Verfaellie, Mieke

Vermeiren, Robert RJM

Wade, Benjamin SC

Wager, Tor

Walter, Henrik

Winternitz, Sherry

Wolff, Jonathan

York, Gerald

Zhu, Ye

Zhu, Xi

Abdallah, Chadi G

Bryant, Richard

Daniels, Judith K

Davidson, Richard J

Fercho, Kelene A

Franz, Carol

Geuze, Elbert

Gordon, Evan M

Kaufman, Milissa L

Kremen, William S

Lagopoulos, Jim

Lanius, Ruth A

Lyons, Michael J

McCauley, Stephen R

McGlinchey, Regina

McLaughlin, Katie A

Milberg, William

Neria, Yuval

Olff, Miranda

Seedat, Soraya

Shenton, Martha

Sponheim, Scott R

Stein, Dan J

Stein, Murray B

Straube, Thomas

Tate, David F

van der Wee, Nic JA

Veltman, Dick J

Wang, Li

Wilde, Elisabeth A

Thompson, Paul M

Kochunov, Peter

Jahanshad, Neda

Morey, Rajendra A

2023-11-01T17:49:04Z

2023-11-01T17:49:04Z

2021-08

2023-11-01T17:49:02Z

A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed which may be partially due to relatively small sample sizes among studies. Altered structural connectivity may be both a neurobiological vulnerability for, and a result of, PTSD. In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3047 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium). Comparing regional white matter metrics across the full brain in 1426 individuals with PTSD and 1621 controls (2174 males/873 females) between ages 18-83, 92% of whom were trauma-exposed, we report associations between PTSD and disrupted white matter organization measured by lower fractional anisotropy (FA) in the tapetum region of the corpus callosum (Cohen's d = -0.11, p = 0.0055). The tapetum connects the left and right hippocampus, for which structure and function have been consistently implicated in PTSD. Results were consistent even after accounting for the effects of multiple potentially confounding variables: childhood trauma exposure, comorbid depression, history of traumatic brain injury, current alcohol abuse or dependence, and current use of psychotropic medications. Our results show that PTSD may be associated with alterations in the broader hippocampal network.

10.1038/s41380-019-0631-x

1359-4184

1476-5578

https://hdl.handle.net/10161/29325

eng

Springer Science and Business Media LLC

Molecular psychiatry

10.1038/s41380-019-0631-x

Brain

Humans

Stress Disorders, Post-Traumatic

Anisotropy

Adolescent

Adult

Aged

Aged, 80 and over

Middle Aged

Female

Male

Young Adult

Diffusion Tensor Imaging

White Matter

Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium.

Journal article

4315

4330

8

Duke

School of Medicine

Clinical Science Departments

Institutes and Centers

Psychiatry & Behavioral Sciences

Institutes and Provost's Academic Units

University Institutes and Centers

Duke Institute for Brain Sciences

Psychiatry, Child & Family Mental Health & Community Psychiatry

Duke-UNC Center for Brain Imaging and Analysis

Published

26