Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium.
dc.contributor.author | Dennis, Emily L | |
dc.contributor.author | Disner, Seth G | |
dc.contributor.author | Fani, Negar | |
dc.contributor.author | Salminen, Lauren E | |
dc.contributor.author | Logue, Mark | |
dc.contributor.author | Clarke, Emily K | |
dc.contributor.author | Haswell, Courtney C | |
dc.contributor.author | Averill, Christopher L | |
dc.contributor.author | Baugh, Lee A | |
dc.contributor.author | Bomyea, Jessica | |
dc.contributor.author | Bruce, Steven E | |
dc.contributor.author | Cha, Jiook | |
dc.contributor.author | Choi, Kyle | |
dc.contributor.author | Davenport, Nicholas D | |
dc.contributor.author | Densmore, Maria | |
dc.contributor.author | du Plessis, Stefan | |
dc.contributor.author | Forster, Gina L | |
dc.contributor.author | Frijling, Jessie L | |
dc.contributor.author | Gonenc, Atilla | |
dc.contributor.author | Gruber, Staci | |
dc.contributor.author | Grupe, Daniel W | |
dc.contributor.author | Guenette, Jeffrey P | |
dc.contributor.author | Hayes, Jasmeet | |
dc.contributor.author | Hofmann, David | |
dc.contributor.author | Ipser, Jonathan | |
dc.contributor.author | Jovanovic, Tanja | |
dc.contributor.author | Kelly, Sinead | |
dc.contributor.author | Kennis, Mitzy | |
dc.contributor.author | Kinzel, Philipp | |
dc.contributor.author | Koch, Saskia BJ | |
dc.contributor.author | Koerte, Inga | |
dc.contributor.author | Koopowitz, Sheri | |
dc.contributor.author | Korgaonkar, Mayuresh | |
dc.contributor.author | Krystal, John | |
dc.contributor.author | Lebois, Lauren AM | |
dc.contributor.author | Li, Gen | |
dc.contributor.author | Magnotta, Vincent A | |
dc.contributor.author | Manthey, Antje | |
dc.contributor.author | May, Geoff J | |
dc.contributor.author | Menefee, Deleene S | |
dc.contributor.author | Nawijn, Laura | |
dc.contributor.author | Nelson, Steven M | |
dc.contributor.author | Neufeld, Richard WJ | |
dc.contributor.author | Nitschke, Jack B | |
dc.contributor.author | O'Doherty, Daniel | |
dc.contributor.author | Peverill, Matthew | |
dc.contributor.author | Ressler, Kerry J | |
dc.contributor.author | Roos, Annerine | |
dc.contributor.author | Sheridan, Margaret A | |
dc.contributor.author | Sierk, Anika | |
dc.contributor.author | Simmons, Alan | |
dc.contributor.author | Simons, Raluca M | |
dc.contributor.author | Simons, Jeffrey S | |
dc.contributor.author | Stevens, Jennifer | |
dc.contributor.author | Suarez-Jimenez, Benjamin | |
dc.contributor.author | Sullivan, Danielle R | |
dc.contributor.author | Théberge, Jean | |
dc.contributor.author | Tran, Jana K | |
dc.contributor.author | van den Heuvel, Leigh | |
dc.contributor.author | van der Werff, Steven JA | |
dc.contributor.author | van Rooij, Sanne JH | |
dc.contributor.author | van Zuiden, Mirjam | |
dc.contributor.author | Velez, Carmen | |
dc.contributor.author | Verfaellie, Mieke | |
dc.contributor.author | Vermeiren, Robert RJM | |
dc.contributor.author | Wade, Benjamin SC | |
dc.contributor.author | Wager, Tor | |
dc.contributor.author | Walter, Henrik | |
dc.contributor.author | Winternitz, Sherry | |
dc.contributor.author | Wolff, Jonathan | |
dc.contributor.author | York, Gerald | |
dc.contributor.author | Zhu, Ye | |
dc.contributor.author | Zhu, Xi | |
dc.contributor.author | Abdallah, Chadi G | |
dc.contributor.author | Bryant, Richard | |
dc.contributor.author | Daniels, Judith K | |
dc.contributor.author | Davidson, Richard J | |
dc.contributor.author | Fercho, Kelene A | |
dc.contributor.author | Franz, Carol | |
dc.contributor.author | Geuze, Elbert | |
dc.contributor.author | Gordon, Evan M | |
dc.contributor.author | Kaufman, Milissa L | |
dc.contributor.author | Kremen, William S | |
dc.contributor.author | Lagopoulos, Jim | |
dc.contributor.author | Lanius, Ruth A | |
dc.contributor.author | Lyons, Michael J | |
dc.contributor.author | McCauley, Stephen R | |
dc.contributor.author | McGlinchey, Regina | |
dc.contributor.author | McLaughlin, Katie A | |
dc.contributor.author | Milberg, William | |
dc.contributor.author | Neria, Yuval | |
dc.contributor.author | Olff, Miranda | |
dc.contributor.author | Seedat, Soraya | |
dc.contributor.author | Shenton, Martha | |
dc.contributor.author | Sponheim, Scott R | |
dc.contributor.author | Stein, Dan J | |
dc.contributor.author | Stein, Murray B | |
dc.contributor.author | Straube, Thomas | |
dc.contributor.author | Tate, David F | |
dc.contributor.author | van der Wee, Nic JA | |
dc.contributor.author | Veltman, Dick J | |
dc.contributor.author | Wang, Li | |
dc.contributor.author | Wilde, Elisabeth A | |
dc.contributor.author | Thompson, Paul M | |
dc.contributor.author | Kochunov, Peter | |
dc.contributor.author | Jahanshad, Neda | |
dc.contributor.author | Morey, Rajendra A | |
dc.date.accessioned | 2023-11-01T17:49:04Z | |
dc.date.available | 2023-11-01T17:49:04Z | |
dc.date.issued | 2021-08 | |
dc.date.updated | 2023-11-01T17:49:02Z | |
dc.description.abstract | A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed which may be partially due to relatively small sample sizes among studies. Altered structural connectivity may be both a neurobiological vulnerability for, and a result of, PTSD. In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3047 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium). Comparing regional white matter metrics across the full brain in 1426 individuals with PTSD and 1621 controls (2174 males/873 females) between ages 18-83, 92% of whom were trauma-exposed, we report associations between PTSD and disrupted white matter organization measured by lower fractional anisotropy (FA) in the tapetum region of the corpus callosum (Cohen's d = -0.11, p = 0.0055). The tapetum connects the left and right hippocampus, for which structure and function have been consistently implicated in PTSD. Results were consistent even after accounting for the effects of multiple potentially confounding variables: childhood trauma exposure, comorbid depression, history of traumatic brain injury, current alcohol abuse or dependence, and current use of psychotropic medications. Our results show that PTSD may be associated with alterations in the broader hippocampal network. | |
dc.identifier | 10.1038/s41380-019-0631-x | |
dc.identifier.issn | 1359-4184 | |
dc.identifier.issn | 1476-5578 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.relation.ispartof | Molecular psychiatry | |
dc.relation.isversionof | 10.1038/s41380-019-0631-x | |
dc.subject | Brain | |
dc.subject | Humans | |
dc.subject | Stress Disorders, Post-Traumatic | |
dc.subject | Anisotropy | |
dc.subject | Adolescent | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Young Adult | |
dc.subject | Diffusion Tensor Imaging | |
dc.subject | White Matter | |
dc.title | Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium. | |
dc.type | Journal article | |
pubs.begin-page | 4315 | |
pubs.end-page | 4330 | |
pubs.issue | 8 | |
pubs.organisational-group | Duke | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Psychiatry & Behavioral Sciences | |
pubs.organisational-group | Institutes and Provost's Academic Units | |
pubs.organisational-group | University Institutes and Centers | |
pubs.organisational-group | Duke Institute for Brain Sciences | |
pubs.organisational-group | Psychiatry, Child & Family Mental Health & Community Psychiatry | |
pubs.organisational-group | Duke-UNC Center for Brain Imaging and Analysis | |
pubs.publication-status | Published | |
pubs.volume | 26 |
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