On the distribution of firing rates in networks of cortical neurons.
| dc.contributor.author | Roxin, Alex | |
| dc.contributor.author | Brunel, Nicolas | |
| dc.contributor.author | Hansel, David | |
| dc.contributor.author | Mongillo, Gianluigi | |
| dc.contributor.author | van Vreeswijk, Carl | |
| dc.date.accessioned | 2021-06-06T18:50:03Z | |
| dc.date.available | 2021-06-06T18:50:03Z | |
| dc.date.issued | 2011-11 | |
| dc.date.updated | 2021-06-06T18:50:02Z | |
| dc.description.abstract | The distribution of in vivo average firing rates within local cortical networks has been reported to be highly skewed and long tailed. The distribution of average single-cell inputs, conversely, is expected to be Gaussian by the central limit theorem. This raises the issue of how a skewed distribution of firing rates might result from a symmetric distribution of inputs. We argue that skewed rate distributions are a signature of the nonlinearity of the in vivo f-I curve. During in vivo conditions, ongoing synaptic activity produces significant fluctuations in the membrane potential of neurons, resulting in an expansive nonlinearity of the f-I curve for low and moderate inputs. Here, we investigate the effects of single-cell and network parameters on the shape of the f-I curve and, by extension, on the distribution of firing rates in randomly connected networks. | |
| dc.identifier | 31/45/16217 | |
| dc.identifier.issn | 0270-6474 | |
| dc.identifier.issn | 1529-2401 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Society for Neuroscience | |
| dc.relation.ispartof | The Journal of neuroscience : the official journal of the Society for Neuroscience | |
| dc.relation.isversionof | 10.1523/jneurosci.1677-11.2011 | |
| dc.subject | Cerebral Cortex | |
| dc.subject | Nerve Net | |
| dc.subject | Neurons | |
| dc.subject | Animals | |
| dc.subject | Normal Distribution | |
| dc.subject | Action Potentials | |
| dc.subject | Neural Inhibition | |
| dc.subject | Nonlinear Dynamics | |
| dc.subject | Models, Neurological | |
| dc.subject | Time Factors | |
| dc.subject | Computer Simulation | |
| dc.title | On the distribution of firing rates in networks of cortical neurons. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Brunel, Nicolas|0000-0002-2272-3248 | |
| pubs.begin-page | 16217 | |
| pubs.end-page | 16226 | |
| pubs.issue | 45 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Physics | |
| pubs.organisational-group | Neurobiology | |
| pubs.organisational-group | Duke Institute for Brain Sciences | |
| pubs.organisational-group | Center for Cognitive Neuroscience | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Trinity College of Arts & Sciences | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.publication-status | Published | |
| pubs.volume | 31 |