Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk.

Abstract

The current study used data from two longitudinal samples to test whether self-regulation, depressive symptoms, and aggression/antisociality were mediators in the relation between a polygenic score indexing serotonin (5-HT) functioning and alcohol use in adolescence. The results from an independent genome-wide association study of 5-hydroxyindoleacetic acid in the cerebrospinal fluid were used to create 5-HT polygenic risk scores. Adolescents and/or parents reported on adolescents' self-regulation (Time 1), depressive symptoms (Time 2), aggression/antisociality (Time 2), and alcohol use (Time 3). The results showed that 5-HT polygenic risk did not predict self-regulation. However, adolescents with higher levels of 5-HT polygenic risk showed greater depression and aggression/antisociality. Adolescents' aggression/antisociality mediated the relation between 5-HT polygenic risk and later alcohol use. Deficits in self-regulation also predicted depression and aggression/antisociality, and indirectly predicted alcohol use through aggression/antisociality. Pathways to alcohol use were especially salient for males from families with low parental education in one of the two samples. The results provide insights into the longitudinal mechanisms underlying the relation between 5-HT functioning and alcohol use (i.e., earlier aggression/antisociality). There was no evidence that genetically based variation in 5-HT functioning predisposed individuals to deficits in self-regulation. Genetically based variation in 5-HT functioning and self-regulation might be separate, transdiagnostic risk factors for several types of psychopathology.

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Published Version (Please cite this version)

10.1017/S095457941700058X

Publication Info

Wang, Frances L, Laurie Chassin, John E Bates, Danielle Dick, Jennifer E Lansford, Gregory S Pettit and Kenneth A Dodge (2017). Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk. Dev Psychopathol. pp. 1–21. 10.1017/S095457941700058X Retrieved from https://hdl.handle.net/10161/15831.

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Scholars@Duke

Lansford

Jennifer Lansford

S. Malcolm Gillis Distinguished Research Professor of Public Policy

Jennifer Lansford is the director of the Center for Child and Family Policy and S. Malcolm Gillis Distinguished Research Professor of Public Policy in the Sanford School of Public Policy.

Dr. Lansford's research focuses on the development of aggression and other behavior problems in youth, with an emphasis on how family and peer contexts contribute to or protect against these outcomes. She examines how experiences with parents (e.g., physical abuse, discipline, divorce) and peers (e.g., rejection, friendships) affect the development of children's behavior problems, how influence operates in adolescent peer groups, and how cultural contexts moderate links between parenting and children's adjustment.

Dodge

Kenneth A. Dodge

William McDougall Distinguished Professor of Public Policy Studies

Kenneth A. Dodge is the William McDougall Distinguished Professor of Public Policy and Professor of Psychology and Neuroscience at Duke University. He is also the founding and past director of the Center for Child and Family Policy, as well as the founder of Family Connects International

Dodge is a leading scholar in the development and prevention of aggressive and violent behaviors. His work provides a model for understanding how some young children grow up to engage in aggression and violence and provides a framework for intervening early to prevent the costly consequences of violence for children and their communities.

Dodge joined the faculty of the Sanford School of Public Policy in September 1998. He is trained as a clinical and developmental psychologist, having earned his B.A. in psychology at Northwestern University in 1975 and his Ph.D. in psychology at Duke University in 1978. Prior to joining Duke, Dodge served on the faculty at Indiana University, the University of Colorado, and Vanderbilt University.

Dodge's research has resulted in the Family Connects Program, an evidence-based, population health approach to supporting families of newborn infants. Piloted in Durham, NC, and formerly known as Durham Connects, the program attempts to reach all families giving birth in a community to assess family needs, intervene where needed, and connect families to tailored community resources. Randomized trials indicate the program's success in improving family connections to the community, reducing maternal depression and anxiety, and preventing child abuse. The model is currently expanding to many communities across the U.S.

Dodge has published more than 500 scientific articles which have been cited more than 120,000 times.

Elected into the National Academy of Medicine in 2015, Dodge has received many honors and awards, including the following:

  • President (Elected), Society for Research in Child Development
  • Fellow, Society for Prevention Research
  • Distinguished Scientist, Child Mind Institute
  • Research Scientist Award from the National Institutes of Health
  • Distinguished Scientific Award for Early Career Contribution from the American Psychological Association
  • J.P. Scott Award for Lifetime Contribution to Aggression Research from the International Society for Research on Aggression
  • Science to Practice Award from the Society for Prevention Research
  • Inaugural recipient of the “Public Service Matters” Award from the Network of Schools of Public Policy, Affairs and Administration
  • Inaugural recipient of the Presidential Citation Award for Excellence in Research from the Society for Research on Adolescence

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