Evaluating Alzheimer Disease With Flortaucipir and Florbetapir PET: A Clinical Case Series.
| dc.contributor.author | James, Olga G | |
| dc.contributor.author | Linares, Alexandra R | |
| dc.contributor.author | Hellegers, Caroline | |
| dc.contributor.author | Doraiswamy, P Murali | |
| dc.contributor.author | Wong, Terence Z | |
| dc.date.accessioned | 2022-01-01T14:48:36Z | |
| dc.date.available | 2022-01-01T14:48:36Z | |
| dc.date.issued | 2021-07 | |
| dc.date.updated | 2022-01-01T14:48:35Z | |
| dc.description.abstract | AbstractEarly, accurate diagnosis of Alzheimer disease (AD) is essential but remains challenging. Neuropathological hallmarks of AD are β-amyloid neuritic plaques and tau protein neurofibrillary tangles. 18F-Florbetapir is one of several available PET tracers for imaging cortical fibrillary β-amyloid plaques. 18F-Flortaucipir PET was recently approved for evaluating the distribution and density of aggregated neurofibrillary tangles. We present cases of mild cognitive impairment or suspected AD to depict the nuances of flortaucipir distribution and scan interpretation as well as how combined information from amyloid and tau PET may help with differential diagnosis and prognosis. | |
| dc.identifier | 00003072-900000000-96257 | |
| dc.identifier.issn | 0363-9762 | |
| dc.identifier.issn | 1536-0229 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Ovid Technologies (Wolters Kluwer Health) | |
| dc.relation.ispartof | Clinical nuclear medicine | |
| dc.relation.isversionof | 10.1097/rlu.0000000000003493 | |
| dc.subject | Humans | |
| dc.subject | Alzheimer Disease | |
| dc.subject | Ethylene Glycols | |
| dc.subject | Aniline Compounds | |
| dc.subject | Carbolines | |
| dc.subject | Positron-Emission Tomography | |
| dc.subject | Aged | |
| dc.subject | Middle Aged | |
| dc.subject | Male | |
| dc.subject | Biomarkers | |
| dc.subject | Cognitive Dysfunction | |
| dc.title | Evaluating Alzheimer Disease With Flortaucipir and Florbetapir PET: A Clinical Case Series. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Wong, Terence Z|0000-0002-1435-3187|0000-0002-3830-1779 | |
| pubs.begin-page | 605 | |
| pubs.end-page | 608 | |
| pubs.issue | 7 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Radiology, Nuclear Medicine | |
| pubs.organisational-group | Medicine, Medical Oncology | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Radiology | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Center for the Study of Aging and Human Development | |
| pubs.organisational-group | Duke Science & Society | |
| pubs.organisational-group | Duke Institute for Brain Sciences | |
| pubs.organisational-group | Medicine, Geriatrics | |
| pubs.organisational-group | Initiatives | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.publication-status | Published | |
| pubs.volume | 46 |
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